Protein folding homeostasis in the Endoplasmic Reticulum
Dal 23/05/2014 ore 12.00 al 15/05/2014 ore 13.30
Aula Magna
CNR IN - Istituto di Neuroscienze
Dip. di Biotecnologie Mediche e Medicina Traslazionale
Via Vanvitelli 32
20129 Milano
Seminario di David Ron, Professor of Cellular Pathophysiology and Clinical Biochemistry, University of Cambridge, UK.
In eukaryotic cells, polypeptides that fail to attain their proper three dimensional structure have deleterious gain-of-function effects on cell function. This process, also referred to as "proteotoxicity", appears to be particularly important to the fate of poorly renewable cells of long-lived organisms (e.g. neurons and insulin-producing islet beta-cell). The progressive aging of the human population has led to an increase in the incidence of diseases hypothesized to be associated with various forms of proteotoxicity. In his lecture, Professor David Ron will give an overview of the molecular events underlying the adaptation of cells to the stress of unfolded proteins in the lumen of endoplasmic reticulum.
Organizzato da:
CNR IN - Istituto di Neuroscienze
Associazione di Biologia Cellulare e del Differenziamento
Università degli Studi di Milano
Referente organizzativo:
Patrizia Rosa
CNR - Istituto di Neuroscienze
CNR - Istituto di Neuroscienze
Via Vanvitelli 32
20129 Milano
p.rosa@in.cnr.it
02 50316974
Modalità di accesso: ingresso libero
Vedi anche: