Insights into structure properties of protein complexes and impact of gene variants

Il 20/12/2013 ore 11.00 - 12.00

Sala Conferenze CNR, Via P. Castellino, 111 Napoli

Franca Fraternali is Professor in Bioinformatics and Computational Biology at the Randall Division of Cell and Molecular Biophysics, King's College London. She will give a seminar on computer simulations of proteins and nucleic acids. Her main focus has been the analysis of protein-protein interaction (PPI) data and their structural properties using methods from structural bioinformatics. In collaboration with W. van Gunsteren (ETH Zu?rich) she has developed an implicit solvation model widely used for the study of folding and unfolding of peptides and proteins. Her methods are part of one of the most popular simulation programs (Gromos11), as well as software widely used for the calculation of PPI 3D-complexes (POPSComp). Recently she has focused her work on computational and statistical methods for the analysis of PPI networks and dynamics. Franca Fraternali studied physical chemistry at the University of Naples before starting an EMBO Fellowship at ETH Zurich. She did postdoctoral work in Strasbourg and at the EMBL Heidelberg. In 2000 she obtained a staff position in the Mathematical Biology Division of the National Institute for Medical Research (MRC NIMR London). Since 2005 she has established her own group at King’s College London within the Randall Division.

Fraternali is on the editorial boards of PloS ONE, Frontiers in Genetics and Proteomics, and is an executive committee member of the Thomas Young Centre. Fraternali is PI or co-PI on grants from the BBSRC, Cancer Research UK and the Wellcome and Leverhulme Trusts. She has strong research connections with ETH Zurich, France, Italy and the USA.

Organizzato da:
IBP, CNR

Referente organizzativo:
Donatella de Pascale
CNR - Istituto di biochimica delle proteine
IBP, CNR Via P. Castellino, 111 80131 Napoli
d.depascale@ibp.cnr.it
081/6132314

Modalità di accesso: ingresso libero