Transcriptional control of stem cell fate | Consiglio Nazionale delle Ricerche

Evento

Il 11/11/2013 ore 12.00 - 13.30

Aula Conferenze CNR
Istituto di Genetica e Biofisica "Adriano Buzzati-Traverso"
Via Pietro Castellino 111
80131 Napoli

Seminario del Dott. Brian Hendrich.

The goal of the group is to understand the transcriptional regulatory mechanisms that underpin the ability of a homogeneous population of pluripotent cells to give rise to the massive heterogeneity existing in somatic tissues. To achieve this we are using a combination of biochemistry, genetics, developmental biology, bioinformatics, ES cell manipulation, in vitro differentiation, proteomics, and gene expression analyses.

Key publications:

1. O’Shaughnessy, A. and Hendrich, B. (2013) CHD4 in the DNA-damage response and cell-cycle progression: not so NuRDY now. Biochem. Soc. Trans. 41(3):777-782. doi:10.1042/BST20130027.

2. Reynolds, N., O’Shaughnessy, A. and Hendrich, B. (2013) "Transcriptional repressors: multifaceted regulators of gene expression" Development, 140(3), 505–512. doi:10.1242/dev.083105

3. Reynolds, N., Latos, P., Hynes-Allen, A., Loos, R., Leaford, D., O’Shaughnessy, A., Mosaku, O., Signolet, J., Brennecke, P., Kalkan, T., Costello, I., Humphreys, P., Mansfield, W., Nakagawa, K., Strouboulis, J., Behrens, A. Bertone, P., and Hendrich, B. (2012) “NuRD suppresses pluripotency gene expression to promote transcriptional heterogeneity and lineage commitment” Cell Stem Cell 10(5): 583-594. 10.1016/j.stem.2012.02.020 Open access: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402183/

4. Latos, P.A., Helliwell, C., Mosaku, O., Dudzinska, D.A., Stubbs, B.,Berdasco, M., Esteller, M., Hendrich, B. (2012) NuRD-dependent DNA methylation prevents ES cells from accessing a trophectoderm fate. Biology Open 1(4):341-352. doi: 10.1242/bio.2012513

5. McDonel, P., Demmers, J., Tan, D.M.W., Watt, F., and Hendrich, B. (2012) “Sin3a is essential for the genome integrity and viability of pluripotent cells.” Developmental Biology 363:62, doi:10.1016/j.ydbio.2011.12.019

6. Reynolds, N., Salmon-Divon, M., Dvinge, H., Balasooriya, G., Leaford, D., Hynes-Allen, A., Behrens, A., Bertone, P. and Hendrich, B. (2012) “NuRD-mediated deacetylation of H3K27 facilitates recruitment of Polycomb Repressive Complex 2 to direct gene repression” EMBO Journal 31:593, doi:10.1038/emboj.2011.431

Organizzato da:
IGB-CNR

Referente organizzativo:
Maurizio D'Esposito
CNR - Istituto di genetica e biofisica "Adriano Buzzati Traverso"
Istituto di Genetica e Biofisica "Adriano Buzzati-Traverso"
Via Pietro Castellino 111
80131 Napoli
alessandra.rogato@igb.cnr.it

Modalità di accesso: ingresso libero