"Molecular Basis for the Differential Prognostic Profiles of the Related Serpins Plasminogen Activator Inhibitors Type 1 and 2 in Cancer "

Il 06/09/2013 ore 14.30 - 15.30

Aula Seminari IBP 3° piano, Istituto di Biochimica delle Proteine, CNR Via P. Castellino, 111 80131 Napoli

Prof. Ranson was Scientific Director of the Illawarra Health and Medical Research Institute from 2009-2012. She has been Associate Professor at School of Biological

Sciences, University of Wollongong since 2006. Her main scientific interests are as follows:
The role of the plasminogen activation system in tumour malignancy and anti-metastasis drug development including: Structure-function relationship of the serpin plasminogen activator inhibitor type 2 (PAI-2) – understanding the “PAI paradox” of serpin expression and cancer outcome.

Development of PAI-2-cytotoxin conjugates as targeted cancer therapeutics: use in combination therapies
Dual targeting small molecule inhibitors of urokinase and sodium hydrogen exchangers

The role of PAI-2 in proteostasis

The role of the plasminogen activation system in invasive Group A Streptococcal infection

Other drug development projectsare on targeting sialyltransferases in cancer and development of an all-in-one, stable pH neutral formulation of 5-fluorouracil and calcium folinate for the treatment of solid tumours

Organizzato da:
CNR, IBP

Referente organizzativo:
Daniela Corda
CNR - Istituto di biochimica delle proteine
Via P. Castellino, 111 80131 Napoli
d.corda@ibp.cnr.it
081/6132536

Modalità di accesso: ingresso libero