The role of the transcription factor Otx2 in embryonic Pluripotent Stem Cells (ESCs and EpiSCs)

Il 24/05/2013 ore 14.30 - 15.30

Aula seminari IBP, Istituto di Biochimica delle Proteine, CNR Via P. Castellino, 111 80131 Napoli

Prof Simeone is Research Director at the Institute of Genetics and Biophysics, CNR, in Naples. Prof. Simeone’s research has mainly been focused on:
-Complexity of the Otx2 gene expression control: transcriptional, post-transcriptional and translational regulation of Otx2 mRNA isoforms co-operate for the specification and maintenance of the forebrain and midbrain identity.
-Role of Otx2 in the neurogenesis of mesencephalic-diencephalic dopaminergic (mdDA) neurons.
-Role of Otx2 in adult mdDA neurons: control of neuron subtype identity; modulation of Dopamine signaling and vulnerability to neurodegeneration .
-Otx1 and Otx2 in initiation, progression and trasmission of desmoplastic medulloblastomas in patched (ptc) aploinsufficient mouse models lacking or over-expressing Otx1 and/or Otx2.
-Identification of Otx1 as a selective marker of aggressive Lymphomas.
-Role of Otx2 in Embryonic Stem Cells (ESCs): generation of Otx2 mutant ESC lines and analysis of the ESC state and pluripotency.
-Role of Otx2 in Epiblast Stem Cells (EpiSCs): analysis of the EpiSC state and pluripotency.
-Role of Otx2 in ESC-based induction of telencephalic neurons.
-Identification and functional analysis of Otx2 target genes in ESCs and EpiSCs.

Organizzato da:
CNR, IBP

Referente organizzativo:
Daniela Corda
CNR - Istituto di biochimica delle proteine
Via P. Castellino, 111 80131 Napoli
d.corda@ibp.cnr.it
081/6132536

Modalità di accesso: ingresso libero