The dangerous genomic liaisons of NF-Y, a pioneer transcription factor

Il 27/05/2013 ore 12.00 - 13.00

Istituto di Genetica e Biofisica "Adriano Buzzati-Traverso"
Via Pietro Castellino 111
80131 Napoli

Seminario del Prof. Roberto Mantovani del Dipartimento di Bioscienze, Università degli Studi di Milano. Research Interests: Understanding the molecular mechanisms underlying regulation of transcription, through the paradigm represented by the CCAAT-binding factor NF-Y, an evolutionarily conserved trimeric factor which regulates many, if not most, mammalian promoters. NF-Y is studied by structural, structure-function and genomic location approaches in humans, yeast and plants. -Identification of genomic targets of transcription factors through location analysis. We are particulalrly focused on TFs that play a role in keratinocyte growth and differentiation and are regulated by the master p63 TF. -Development of assays to study small compounds that interfere with transcriptional regulation.

Organizzato da:
CNR - Istituto di Genetica e Biofisica "Adriano Buzzati-Traverso"

Referente organizzativo:
Pasquale Verde
CNR - Istituto di genetica e biofisica "Adriano Buzzati Traverso"
Via Pietro Castellino 111
80131 Napoli
pasquale.verde@igb.cnr.it

Modalità di accesso: ingresso libero