The role of X-linked intellectual disability genes in synapse functions

Il 13/05/2013 ore 12.00 - 13.00

Istituto di Genetica e Biofisica "Adriano-Buzzati-Traverso", CNR
Via Pietro Castellino 111
80131 Napoli

Seminario della Dott.ssa Maria Passafaro dell'Istituto di Neuroscienze del CNR di Milano. Her interest is centred on understanding the functional role of proteins associated to postsynaptic membrane of excitatory synapses in the mammalian central nervous system. In particular, we focused to study the role of various components of postsynaptic density (PSD) and of glutamate receptors. Currently, the laboratory is following a main project in the molecular regulation of glutamate receptors trafficking at synapses by Myosin motor.                                                                                   

PUBLICATIONS

• Correia SS, Bassani S, Brown TC, Lisé MF, Backos DS, El-Husseini A, Passafaro M, Esteban JA (2008) Motor protein-dependent transport of AMPA receptors into spines during long-term potentiation. Nat. Neurosci. 11:457-66.
• Saglietti L, Dequidt C, Kamieniarz K, Rousset MC, Valnegri P, Thoumine O, Beretta F, Fagni L, Choquet D, Sala C, Sheng M, Passafaro M (2007) Extracellular interactions between GluR2 and N-cadherin in spine regulation. Neuron 54:461-77.
• Passafaro M, Nakagawa T, Sala C, Sheng M (2003) Induction of dendritic spines by an extracellular domain of AMPA receptor subunit GluR2. Nature 424:677-81.
• Passafaro M, Piëch V, Sheng M (2001) Subunit-specific temporal and spatial patterns of AMPA receptor exocytosis in hippocampal neurons. Nat. Neurosci. 4:917-26.
• Passafaro M, Sala C, Niethammer M, Sheng M (1999) Microtubule binding by CRIPT and its potential role in the synaptic clustering of PSD-95. Nat. Neurosci. 2:1063-9.

Organizzato da:
IGB-CNR

Referente organizzativo:
Maria Pia Miano
CNR - Istituto di genetica e biofisica "Adriano Buzzati Traverso"
Via Pietro Castellino, 111
80131 Napoli
mariag.miano@igb.cnr.it

Modalità di accesso: ingresso libero