Gorillas Out of the Mist: Unravelling the Fog Surrounding Another Genome

Il 15/04/2013 ore 12.00 - 13.00

Aula Conferenze CNR
Istituto di genetica e Biofisica "Adriano Buzzati-Traverso", CNR
Via Pietro Castellino 111
80131 Napoli

Seminario della Dott.ssa Bryndis Yngvadottir del Division of Biological Anthropology del University of Cambridge

RESEARCH INTERESTS

My primary research interests are in the field of human evolution. Specifically, they include the subjects of genetic variation in humans and non-human great apes, natural selection, cultural history and genome-wide comparison of closely related populations and species.

My current work is focused on analysing genetic variation in modern gorillas to make inferences about their demographic past. To this end I am using the de novo assembly of Kamilah, a western lowland gorilla, as well as reduced representation sequence data from additional individuals representing both the eastern and western species.

Publications

Scally A, Dutheil JY, Hillier LW, Jordan GE, Goodhead I, Herrero J, Hobolth A, Lappalainen T, Mailund T, Marques-Bonet T, McCarthy S, Montgomery SH, Schwalie PC, Tang YA, Ward MC, Xue Y, Yngvadottir B et al. 2012. Insights into hominid evolution from the gorilla genome sequence. Nature 483(7388):169-175.

MacArthur DG, Balasubramanian S, Frankish A, Huang N, Morris J, Walter K, Jostins L, Habegger L, Pickrell JK, Montgomery SB, Albers CA, Zhang ZD, Conrad DF, Lunter G, Zheng H, Ayub Q, DePristo MA, Banks E, Hu M, Handsaker RE, Rosenfeld JA, Fromer M, Jin M, Mu XJ, Khurana E, Ye K, Kay M, Saunders GI, Suner MM, Hunt T, Barnes IH, Amid C, Carvalho-Silva DR, Bignell AH, Snow C, Yngvadottir B et al. 2012. A systematic survey of loss-of-function variants in human protein-coding genes. Science 335(6070):823-828.

Xue Y, Zhang X, Huang N, Daly A, Gillson CJ, MacArthur DG, Yngvadottir B, Nica AC, Woodwark C, Chen Y, Conrad DF, Ayub Q, Mehdi SQ, Li P and Tyler-Smith C. 2009. Population differentiation as an indicator of recent positive selection in humans: an empirical evaluation. Genetics 183(3):1065-77.

Yngvadottir B, Xue Y, Searle S, Hunt S, Delgado M, Morrison J, Whittaker P, Deloukas P and Tyler-Smith C. 2009. A genome-wide survey of the prevalence and evolutionary forces acting on human nonsense SNPs. American Journal of Human Genetics 84(2):224-34.

Yngvadottir B, MacArthur DG, Jin H and Tyler-Smith C. 2009. The promise and reality of personal genomics. Genome Biology 10(9):237.

Yngvadottir B, Carvalho-Silva DR. 2007. Reconstructing human history using autosomal, Y-chromosomal and mitochondrial markers. In Encyclopedia of Life Sciences. Chichester: John Wiley & Sons, Inc. DOI: 10.1002/9780470015902.a0020819

Yngvadottir B. 2007. Insights into modern disease from our distant evolutionary past. European Journal of Human Genetics 15(5):603-606.

Gutala R, Carvalho-Silva DR, Jin L, Yngvadottir B, Avadhanula V, Nanne K, Singh L, Chakraborty R, and Tyler-Smith C. 2006. A shared Y-chromosomal heritage between Muslims and Hindus in India. Human Genetics 120(4):543-551.

Xue Y, Daly A, Yngvadottir B, Liu M, Coop G, Kim Y, Sabeti P, Chen Y, Stalker J, Huckle E et al. 2006. Spread of an inactive form of caspase-12 in humans is due to recent positive selection. American Journal of Human Genetics 78(4):659-670.

Organizzato da:
CNR - Istituto di Genetica e Biofisica "Adriano Buzzati-Traverso"

Referente organizzativo:
Vincenza Colonna
CNR - Istituto di genetica e biofisica "Adriano Buzzati Traverso"
Istituto di genetica e Biofisica "Adriano Buzzati-Traverso", CNR
Via Pietro Castellino 111
80131 Napoli
vincenza.colonna@igb.cnr.it

Modalità di accesso: ingresso libero