The MitoDrome database annotates the complete set of Drosophila melanogaster nuclear genes encoding for mitochondrial proteins in order to contribute to their functional characterization. The data collected in MitoDrome derives from the comparison of Human mitochondrial proteins available in SWISSPROT vs. the Drosophila genome, ESTs and cDNA sequences available in the FlyBase database. According to the results, each Drosophila gene sharing significant homology with a human mitochondrial protein was classified as a putative Drosophila mitochondrial gene and annotated in MitoDrome. Using the same approach MitoDrome has performed the annotation, at genomic level, of the complete set of OXPHOS system genes in two more species of diptera, the Drosophila pseudoobscura and Anopheles gambiae. All these genes have been compared with each other and with their human counterpart and clustered in families. Additional information provided by MitoDrome includes data on mutant insertion alleles of the OXPHOS genes in D. melanogaster.
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sequenze di acidi nucleici e proteine