AMPLITUDE "Advanced Multimodal Photonics Laser Imaging Tool for Urothelial Diagnosis in Endoscopy" (DFM.AD005.284)

Thematic area

Physical sciences and technologies of matter

Project area

Structure responsible for the research project

National Institute of Optics (INO)

Project manager

FRANCESCOSAVERIO PAVONE
Phone number: 0554572480
Email: francesco.pavone@lens.unifi.it

Abstract

There is an absence of lasers with the necessary wavelengths and characteristics to access the possibilities for deeper highresolution biological tissue imaging in the third bio-window between 1650 nm and 1870 nm. Motivated by recent breakthrough results in multi-photon imaging at twice the depths currently achievable, we will meet the urgent need for new sources to address the outstanding research questions in this spectral region. Results will guide and enable instrument development in this appealing and relatively unexplored biophotonics imaging wavelength range. The AMPLITUDE consortium proposes a new concept of label-free, multi-modal microscopy and endoscopic imaging operating in this new wavelength region with multiple imaging and spectroscopic technologies, including NIR confocal reflectance microscopy, multi-photon microscopy and spontaneous Raman spectroscopy. By progressing ultrafast fibre laser developments at 1700 nm, we will deliver new imaging capabilities in an appropriate form factor and at cost suitable for widespread adoption. This will be further enhanced by providing additional output at 850 nm using second harmonic generation from one integrated laser device.

Start date of activity

01/01/2020

Keywords

Biophotonics, Imaging, image and data processing

Last update: 19/06/2025