AIRC-PANCREAS -- Metabolic regulation of the DNA demethylation enzymatic machinery in pancreatic cance (DIT.AD021.114)
Area tematica
Ingegneria, ICT e tecnologie per l'energia e i trasporti
Area progettuale
Matematica Applicata (DIT.AD021)Struttura responsabile del progetto di ricerca
Istituto di analisi dei sistemi ed informatica "Antonio Ruberti" (IASI)
Responsabile di progetto
FRANCESCO SPALLOTTA
Telefono: 0649937102
E-mail: francesco.spallotta@iasi.cnr.it
Abstract
Background: Epidemiological studies have pointed out a correlation between dysmetabolism and gastrointestinal tumors, including pancreatic cancer. Dysmetabolism and consequent altered cellular metabolite availability impacts on the epigenetic landscape. DNA methylation and its enzymatic machinery are particularly sensitive to metabolic alterations. Indeed, the consequent alteration of cytosine methylation pattern affects stably cell transcriptome and leads to the establishment of the so- called "epi-metabolic memory". Recently, my studies shed light on the stroma as a sensor of dysmetabolism and a keeper of the epi-metabolic memory. Pancreatic ductal adenocarcinoma (PDAC) is characterized by a scarce proportion of malignant cells and a preponderant desmoplastic stroma, abundant in extracellular matrix deposition, cancer-associated fibroblasts (CAFs), disorganized endothelium and exhausted immune cells. PDAC stroma hampers pancreatic tissue homeostasis and plays a pivotal role in refractory to therapy. Expected results: Achievements of this proposal will increase the knowledge about the dysmetabolism impact on pancreatic cancer tumorigenesis and progression and will shed light on no
Data inizio attività
02/01/2020
Parole chiave
Metabolic regulation, Pancreas cancer
Ultimo aggiornamento: 07/06/2025