MarPipe (DSB.AD007.139)

Area tematica

Scienze biomediche

Area progettuale

Struttura responsabile del progetto di ricerca

Istituto di Biochimica e Biologia Cellulare (IBBC)

Responsabile di progetto

DONATELLA DE PASCALE
Telefono: 0816132314
E-mail: d.depascale@ibp.cnr.it

Abstract

MarPipe is a consortium of 11 partners (IBP-CNR, SZN, UiT, UNIABDN, GEOMAR, KULeuven, UCC, eCOAST,
MEDINA, MicroDish, Italbiotec) based in 8 countries (I, N, UK, D, B, IRL, E, NL), including 3 from the nonacademic
sector. We will train 11 ESRs in marine drug-discovery, providing these researchers with unique skills
toward becoming world leaders in this research field and to advance their careers in academia or industry. MarPipe
PhDs will be trained in a programme including training-by-research, joint courses of technical, scientific and
transferrable skills, active participation to public scientific events, and an intense inter-sectoral networking exchange
plan.

Obiettivi

Marine organisms have the capacity to produce a variety of biologically potent natural products, including antibiotic
and anticancer compounds. MarPipe aims at further development of antimicrobial and anticancer lead compounds
originating from a previous EU project (PharmaSea), and will also explore the bioactivity of deep-sea samples
(5000m) collected during the recent Eurofleet-2 project in the sub-Antarctic. The PhD students will thus be involved
in all phases of the drug discovery pipeline, from isolation of new microbial strains to pre-clinical development of lead
compounds. Importantly, they will also be trained to overcome existing bottlenecks in the field, e.g. low yields and
low chemodiversity, isolation of known compounds, toxicity of compounds.

Data inizio attività

01/11/2016

Parole chiave

antimicrobials, extreme environments, marine source

Ultimo aggiornamento: 02/06/2025