PRIN2017-20175XBSX4_006-Davide Pirolli (DCM.AD007.090)
Area tematica
Scienze chimiche e tecnologie dei materiali
Area progettuale
Chimica e materiali per la salute e le scienze della vita (DCM.AD007)Struttura responsabile del progetto di ricerca
Istituto di Scienze e Tecnologie Chimiche "Giulio Natta" (SCITEC)
Altre strutture che collaborano al progetto di ricerca
Responsabile di progetto
DAVIDE PIROLLI
Telefono: 06301551535
E-mail: davide.pirolli@cnr.it
Abstract
In recent years, the Hedgehog (Hh) pathway has emerged as the most promising target for the development of anticancer drugs. A variety of Smo antagonists have been developed but their clinical use has failed due to different issues such as pharmacokinetics and the emergence of drug resistance. For this reason, the discovery of new effective Hh inhibitors is needed. The present project will be devoted to the modulation of the Hh signaling pathway by new chemical entities (NCE) designed by coupling synthetic feasibility criteria with pharmacophoric and steric features. In particular, this ambitious proposal would lead to selection, priorization and optimization of new classes of compounds by a ligand-based molecular modeling or strusture-based approaches and their synthesis through innovative and sustainable chemical processes, a priority of modern chemistry. Furthermore, the study will be aimed at developing of suitable delivery technologies in order to provide a viable alternative for cancer therapy.
Data inizio attività
29/10/2019
Parole chiave
drug discovery and design, structural biology and crystallography, green chemistry
Ultimo aggiornamento: 12/10/2024