"Epigenetics and nuclear structures: the role of Lamin A in muscle differentiation"

Il 14/06/2013 ore 14.30 - 15.30

Aula seminari Ibp, Cnr via P. Castellino, 111 80131 Napoli

Dr Chiara Lanzuolo from the Institute of Cellular Biology and Neurobiology, CNR, Rome

studies the Polycomb group (PcG) of proteins that is part of a conserved epigenetic cell memory system that prevents changes in cell lineage identity by maintaining transcription patterns through cell divisions via chromatin structure. Although it is clear that chromatin organization and epigenetic regulation are altered in diseases caused by mutantions in Lamin A, virtually nothing is known about the specific functions of lamins in these processes under normal physiological conditions. We hypothesize an involvement of lamin in the coordination of gene expression regulating contemporary sub-set of genes throughout direct or indirect interactions with Polycomb complexes. Our studies are focused on physiological processes such as differentiation and senescence and pathological conditions as premature senescence and lamin disorders to find the role Lamin A in the regulation of gene expression. To this aim we combine molecular and cellular biology, the use of high-resolution techniques, such as Chip, FISH, 4C and time-lapse microscopy supported by high performance computing for the analysis of data. The ultimate objective will be to produce the fundamental knowledge of functional interactions between Polycomb repressive complexes and Lamin A that could help to untangle the intricate cascade of events at the basis of lamin related diseases, providing new tools for preclinical studies.

Organizzato da:
Cnr, Ibp

Referente organizzativo:
Daniela Corda
CNR - Istituto di biochimica delle proteine
Via P. Castellino, 111 80131 Napoli
d.corda@ibp.cnr.it
081/6132536

Modalità di accesso: ingresso libero