Protein quality control in the early secretory pathway
Il 10/11/2017 ore 14.30 - 15.30
Sala Conferenze CNR, Area della Ricerca Na1, Via P. Castellino, 111 80131 Napoli
Prof. Elizabeth A. Miller from MRC Laboratory of Molecular Biology Cambridge Biomedical Campus (Cambridge, UK) will give a seminar on the basic mechanisms of secretory protein biogenesis, focusing on protein quality control within the ER.
Cellular physiology relies on the accurate deployment of every gene product to the correct cellular compartment. Fully one third of the proteins encoded in eukaryotic genomes navigate the secretory pathway, entering this system via the endoplasmic reticulum (ER). Prof. Miller's team uses the budding yeast, Saccharomyces cerevisiae, as a model system, which affords facile biochemical, genetic, genomic and proteomic tools. By using such a tractable model system, they can rapidly discover new pathways and dissect mechanisms that may be directly relevant to a number of human diseases, most notably cystic fibrosis and similar diseases of protein misfolding.
Istituto di biochimica delle proteine (Ibp-Cnr)
Via P. Castellino, 111 80131 Napoli
Modalità di accesso: ingresso libero