A novel glycerophosphodiester phosphodiesterase GDE5 controls skeletal muscle development via a non-enzymatic mechanism (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• A novel glycerophosphodiester phosphodiesterase GDE5 controls skeletal muscle development via a non-enzymatic mechanism (Articolo in rivista) (literal)

Anno

• 2010-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1074/jbc.M110.106708 (literal)

Alternative label

• Okazaki Y.; Ohshima N.; Yoshizawa I.; Kamei Y.; Mariggiò S.; Okamoto K.; Maeda M.; Nogusa Y.; Fujioka Y.; Izumi T.; Ogawa Y.; Shiro Y.; Wada M.; Kato N.; Corda D.; Yanaka N. (2010)
  A novel glycerophosphodiester phosphodiesterase GDE5 controls skeletal muscle development via a non-enzymatic mechanism
  in The Journal of biological chemistry (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Okazaki Y.; Ohshima N.; Yoshizawa I.; Kamei Y.; Mariggiò S.; Okamoto K.; Maeda M.; Nogusa Y.; Fujioka Y.; Izumi T.; Ogawa Y.; Shiro Y.; Wada M.; Kato N.; Corda D.; Yanaka N. (literal)

Pagina inizio

• 27652 (literal)

Pagina fine

• 27663 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 285 (literal)

Rivista

• ?The ?Journal of biological chemistry (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

• PubMed N. e link: PMID: 20576599 http://www.ncbi.nlm.nih.gov/pubmed/20576599 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 36 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Hiroshima Univ, Dept Mol & Appl Biosci, Grad Sch Biosphere Sci, Higashihiroshima 7398528, Japan Gunma Univ, Dept Biochem, Grad Sch Med, Gunma 3718511, Japan Tokyo Med & Dent Univ, Dept Mol Med & Metab, Med Res Inst, Tokyo 1138510, Japan Consorzio Mario Negri Sud, Dept Cell Biol & Oncol, I-66030 Santa Maria Imbaro, Italy CNR, Inst Prot Biochem, I-80131 Naples, Italy RIKEN SPring 8 Ctr, Harima Inst, Hongo 6795148, Japan Hiroshima Univ, Dept Human Sci, Grad Sch Integrated Arts & Sci, Higashihiroshima 7398521, Japan (literal)

Titolo

• A novel glycerophosphodiester phosphodiesterase GDE5 controls skeletal muscle development via a non-enzymatic mechanism (literal)

Abstract

• Mammalian glycerophosphodiester phosphodiesterases (GP-PDEs) have been recently identified and shown to be implicated in several physiological functions. This study isolated a novel GP-PDE, GDE5, and showed that GDE5 selectively hydrolyzes glycerophosphocholine (GroPCho) and controls skeletal muscle development. We show that GDE5 expression was reduced in atrophied skeletal muscles in mice, and that decreasing GDE5 abundance promoted myoblastic differentiation, suggesting that decreased GDE5 expression has a counter-regulatory effect on the progression of skeletal muscle atrophy. Forced expression of full-length GDE5 in cultured myoblasts suppressed myogenic differentiation. Unexpectedly, a truncated GDE5 (GDE5DeltaC471), that contained a GP-PDE sequence identified in other GP-PDEs, but lacked GroPCho phosphodiesterase activity, showed a similar inhibitory effect. Furthermore, transgenic mice specifically expressing GDE5DeltaC471 in skeletal muscle showed less skeletal muscle mass, and especially type II fiber-rich muscles. These results indicate that GDE5 negatively regulates skeletal muscle development even without GroPCho phosphodiesterase activity, providing novel insight into the biological significance of mammalian GDE function in a non-enzymatic mechanism. (literal)

Prodotto di

• Dr.ssa CORDA Meccanismi molecolari coinvolti nella trasformazione neoplastica: identificazione di bersagli specifici per lo sviluppo di nuovi farmaci (SV.P15.014.001) (Modulo)
• Institute of protein biochemistry (IBP) (Istituto)

Autore CNR

• STEFANIA MARIGGIO' (Persona)
• DANIELA CORDA (Unità di personale esterno)

Insieme di parole chiave

• Keywords of "A novel glycerophosphodiester phosphodiesterase GDE5 controls skeletal muscle development via a non-enzymatic mechanism" (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute of protein biochemistry (IBP) (Istituto)
• Dr.ssa CORDA Meccanismi molecolari coinvolti nella trasformazione neoplastica: identificazione di bersagli specifici per lo sviluppo di nuovi farmaci (SV.P15.014.001) (Modulo)

Autore CNR di

• STEFANIA MARIGGIO' (Persona)
• DANIELA CORDA (Unità di personale esterno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• ?The ?Journal of biological chemistry (Rivista)

Insieme di parole chiave di

• Keywords of "A novel glycerophosphodiester phosphodiesterase GDE5 controls skeletal muscle development via a non-enzymatic mechanism" (Insieme di parole chiave)