Genetic association of alpha2-macroglobulin polymorphisms with AD in southern Italy. (Articolo in rivista)

Type
Label
  • Genetic association of alpha2-macroglobulin polymorphisms with AD in southern Italy. (Articolo in rivista) (literal)
Anno
  • 2002-01-01T00:00:00+01:00 (literal)
Alternative label
  • Zappia M,1; Cittadella R,2; Manna I,2; Nicoletti G,2; Andreoli V,2; Bonavita S,3; Gambardella A,1; Quattrone A. 1-2 (2002)
    Genetic association of alpha2-macroglobulin polymorphisms with AD in southern Italy.
    in Neurology
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Zappia M,1; Cittadella R,2; Manna I,2; Nicoletti G,2; Andreoli V,2; Bonavita S,3; Gambardella A,1; Quattrone A. 1-2 (literal)
Pagina inizio
  • 756 (literal)
Pagina fine
  • 758 (literal)
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  • 59 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto
  • We report the association of alpha2Macroglobulin Ins/Del and Val1000Ile polymorphisms with Alzheimer's Disease (AD) in a southern Italian population, suggesting that, in our population, both polymorphisms could be markers of predisposition to AD. (literal)
Note
  • ISI Web of Science (WOS) (literal)
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  • 1, Institute of Neurology, School of Medicine, Catanzaro, Italy. 2, Institutes of Neurological Sciences, National Research Council, Piano Lago di Mangone- Cosenza; 3, Department of Neurology, Second University of Naples; (literal)
Titolo
  • Genetic association of alpha2-macroglobulin polymorphisms with AD in southern Italy. (literal)
Abstract
  • The authors investigated the segregation of two polymorphisms of the alpha2-macroglobulin gene (A2M-I/D and A2M-Ile1000Val) in patients with sporadic AD from southern Italy. The A2M-I and A2M-Val1000 alleles were more frequent in cases than in controls, and this effect was independent from the APOE-epsilon4 status as well as from the age at onset of AD. Moreover, subjects carrying the A2M genotype I/I-Val/Val had a threefold increase of risk for AD. These data support a population-based susceptibility for AD linked to A2M polymorphisms. (literal)
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