@prefix pubblicazioni: . @prefix unitaDiPersonaleInterno: . @prefix prodotto: . unitaDiPersonaleInterno:MATRICOLA8238 pubblicazioni:autoreCNRDi prodotto:ID4606 . unitaDiPersonaleInterno:MATRICOLA8423 pubblicazioni:autoreCNRDi prodotto:ID4606 . @prefix prodottidellaricerca: . @prefix istituto: . istituto:CDS059 prodottidellaricerca:prodotto prodotto:ID4606 . @prefix modulo: . modulo:ID2664 prodottidellaricerca:prodotto prodotto:ID4606 . @prefix rdf: . prodotto:ID4606 rdf:type prodotto:TIPO1101 . @prefix retescientifica: . prodotto:ID4606 rdf:type retescientifica:ProdottoDellaRicerca . @prefix rdfs: . prodotto:ID4606 rdfs:label "DNA end binding activity and Ku70/80 heterodimer expression in human colorectal tumor. (Articolo in rivista)"@en . @prefix xsd: . prodotto:ID4606 pubblicazioni:anno "2005-01-01T00:00:00+01:00"^^xsd:gYear . @prefix skos: . prodotto:ID4606 skos:altLabel "
Mazzarelli P., Parrella P., Seripa D., Signori E., Perrone G., Rabitti C., Borzomati D., Gabbrielli A., Matera M.G., Gravina C., Caricato M., Poeta M.L., Rinaldi M., Valeri S., Coppola R., Fazio V.M.. (2005)
DNA end binding activity and Ku70/80 heterodimer expression in human colorectal tumor.
in World Journal of Gastroenterology
"^^rdf:HTML ; pubblicazioni:autori "Mazzarelli P., Parrella P., Seripa D., Signori E., Perrone G., Rabitti C., Borzomati D., Gabbrielli A., Matera M.G., Gravina C., Caricato M., Poeta M.L., Rinaldi M., Valeri S., Coppola R., Fazio V.M.."^^xsd:string ; pubblicazioni:paginaInizio "6694"^^xsd:string ; pubblicazioni:paginaFine "6700"^^xsd:string ; pubblicazioni:numeroVolume "11/42"^^xsd:string . @prefix ns11: . prodotto:ID4606 pubblicazioni:rivista ns11:ID173578 ; skos:note "ISI Web of Science (WOS)"^^xsd:string ; pubblicazioni:affiliazioni "Paola Mazzarelli, Emanuela Signori, Maria Luana Poeta, Vito Michele Fazio, Laboratory of Molecular Medicine and Biotechnology, Interdisciplinary Center for Biomedical Research, Universit\u00E0 Campus Bio-Medico, Rome 00155, Italy;\n\nPaola Parrella, Davide Seripa, Maria Giovanna Matera, Carolina Gravina, Vito Michele Fazio, Laboratory of Gene Therapy and Oncology, IRCCS \u0093Casa Sollievo della Sofferenza\u0094 Hospital, San Giovanni Rotondo (FG) 71013, Italy;\n\nGiuseppe Perrone, Carla Rabitti, Service of Histopathology, Universit\u00E0 Campus Bio-Medico, Rome 00155, Italy;\n\nDomenico Borzomati, Marco Caricato, Sergio Valeri, Roberto Coppola, Department of General Surgery, Universit\u00E0 Campus Bio-Medico, Rome 00155, Italy;\n\nArmando Gabbrielli, Department of Digestive Disease, Universit\u00E0 Campus Bio-Medico, Rome 00155, Italy;\n\nEmanuela Signori, Monica Rinaldi, Vito Michele Fazio, CNR Gene-Medicine Division, Section of Molecular Medicine, Institute of Neurobiology and Molecular Medicine, Rome 00133, Italy;\n\n"^^xsd:string ; pubblicazioni:titolo "DNA end binding activity and Ku70/80 heterodimer expression in human colorectal tumor."^^xsd:string ; prodottidellaricerca:abstract "AIM: To determine the DNA binding activity and protein levels of the Ku70/80 heterodimer, the functional mediator of the NHEJ activity, in human colorectal carcinogenesis. METHODS: The Ku70/80 DNA-binding activity was determined by electrophoretic mobility shift assays in 20 colon adenoma and 15 colorectal cancer samples as well as matched normal colonic tissues. Nuclear and cytoplasmic protein expression was determined by immunohistochemistry and Western blot analysis. RESULTS: A statistically significant difference was found in both adenomas and carcinomas as compared to matched normal colonic mucosa (P<0.00). However, changes in binding activity were not homogenous with approximately 50% of the tumors showing a clear increase in the binding activity, 30% displaying a modest increase and 15% showing a decrease of the activity. Tumors, with increased DNA-binding activity, also showed a statistically significant increase in Ku70 and Ku86 nuclear expression, as determined by Western blot and immunohistochemical analyses (P<0.001). Cytoplasmic protein expression was found in pathological samples, but not in normal tissues either from tumor patients or from healthy subjects. CONCLUSION: Overall, our DNA-binding activity and protein level are consistent with a substantial activation of the NHEJ pathway in colorectal tumors. Since the NHEJ is an error prone mechanism, its abnormal activation can result in chromosomal instability and ultimately lead to tumorigenesis.\n\n" ; prodottidellaricerca:prodottoDi istituto:CDS059 , modulo:ID2664 ; pubblicazioni:autoreCNR unitaDiPersonaleInterno:MATRICOLA8423 , unitaDiPersonaleInterno:MATRICOLA8238 . @prefix parolechiave: . prodotto:ID4606 parolechiave:insiemeDiParoleChiave . ns11:ID173578 pubblicazioni:rivistaDi prodotto:ID4606 . parolechiave:insiemeDiParoleChiaveDi prodotto:ID4606 .