Analysis of diltiazem and its related substances by HPLC and HPLC/MS (Articolo in rivista)

Type
Label
  • Analysis of diltiazem and its related substances by HPLC and HPLC/MS (Articolo in rivista) (literal)
Anno
  • 2005-01-01T00:00:00+01:00 (literal)
Alternative label
  • M. G. Quaglia, E. Donati, S. Fanali, E. Bossù. A. Montinaro, F. Buiarelli (2005)
    Analysis of diltiazem and its related substances by HPLC and HPLC/MS
    in Journal of pharmaceutical and biomedical analysis (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • M. G. Quaglia, E. Donati, S. Fanali, E. Bossù. A. Montinaro, F. Buiarelli (literal)
Pagina inizio
  • 695 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 37 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Titolo
  • Analysis of diltiazem and its related substances by HPLC and HPLC/MS (literal)
Abstract
  • Diltiazem (DTZ) is an optically active calcium channel blocker having a benzodiazepine structure. The drug used in therapy is (+)-cisdiltiazem with configuration (2S,3S). To describe the analytical profile of DTZ different stationary phases (RP-18, RP-8, monolithic support) were tested. The best separation of DTZ from A, B, E and F was obtained using as stationary phase a RP-8 or a monolithic RP-18. The characterization of impurities was carried out using two analytical systems, HPLC and HPLC/MS. (literal)
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