Enhanced Bioactivity of Internally Functionalized Cationic Dendrimers with PEG Cores (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Enhanced Bioactivity of Internally Functionalized Cationic Dendrimers with PEG Cores (Articolo in rivista) (literal)

Anno

• 2012-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1021/bm301384y (literal)

Alternative label

• Albertazzi, Lorenzo; Mickler, Frauke M.; Pavan, Giovanni M.; Salomone, Fabrizio; Bardi, Giuseppe; Panniello, Mariangela; Amir, Elizabeth; Kang, Taegon; Killops, Kato L.; Braeuchle, Christoph; Amir, Roey J.; Hawker, Craig J. (2012)
  Enhanced Bioactivity of Internally Functionalized Cationic Dendrimers with PEG Cores
  in Biomacromolecules
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Albertazzi, Lorenzo; Mickler, Frauke M.; Pavan, Giovanni M.; Salomone, Fabrizio; Bardi, Giuseppe; Panniello, Mariangela; Amir, Elizabeth; Kang, Taegon; Killops, Kato L.; Braeuchle, Christoph; Amir, Roey J.; Hawker, Craig J. (literal)

Pagina inizio

• 4089 (literal)

Pagina fine

• 4097 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 13 (literal)

Rivista

• Biomacromolecules (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 9 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 12 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• University of California Santa Barbara; Istituto Italiano di Tecnologia - IIT; Consiglio Nazionale delle Ricerche (CNR)NANO; Istituto Italiano di Tecnologia - IIT; University of Munich; CIPSM; Univ Appl Sci So Switzerland SUPSI; United States Army; Tel Aviv University (literal)

Titolo

• Enhanced Bioactivity of Internally Functionalized Cationic Dendrimers with PEG Cores (literal)

Abstract

• Hybrid dendritic-linear block copolymers based on a 4-arm poly(ethylene glycol) (PEG) core were synthesized using an accelerated AB(2)/CD2 dendritic growth approach through orthogonal amine/epoxy and thiol-yne chemistries. The biological activity of these 4-arm and the corresponding 2-arm hybrid dendrimers revealed an enhanced, dendritic effect with an exponential increase in cell internalization concomitant with increasing amine end groups and low cytotoxicity. Furthermore, the ability of these hybrid dendrimers to induce endosomal escape combined with their facile and efficient synthesis makes them attractive platforms for gene transfection. The 4-arm-based dendrimer showed significantly improved DNA binding and gene transfection capabilities in comparison with the 2-arm derivative. These results combined with the MD simulation indicate a significant effect of both the topology of the PEG core and the multivalency of these hybrid macromolecules on their DNA binding and delivery capablities. (literal)

Prodotto di

• Progettazione ed applicazioni di Nanobiotecnologie (MD.P06.022.002) (Modulo)

Autore CNR

• LORENZO ALBERTAZZI (Unità di personale esterno)

Incoming links:

Autore CNR di

• LORENZO ALBERTAZZI (Unità di personale esterno)

Prodotto

• Progettazione ed applicazioni di Nanobiotecnologie (MD.P06.022.002) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Biomacromolecules (Rivista)