Discovery of a new family of carbonic anhydrases in the malaria pathogen Plasmodium falciparum-The eta-carbonic anhydrases (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Discovery of a new family of carbonic anhydrases in the malaria pathogen Plasmodium falciparum-The eta-carbonic anhydrases (Articolo in rivista) (literal)

Anno

• 2014-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.bmcl.2014.08.015 (literal)

Alternative label

• Del Prete, Sonia; Vullo, Daniela; Fisher, Gillian M.; Andrews, Katherine T.; Poulsen, Sally-Ann; Capasso, Clemente; Supuran, Claudiu T. (2014)
  Discovery of a new family of carbonic anhydrases in the malaria pathogen Plasmodium falciparum-The eta-carbonic anhydrases
  in Bioorganic & medicinal chemistry letters (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Del Prete, Sonia; Vullo, Daniela; Fisher, Gillian M.; Andrews, Katherine T.; Poulsen, Sally-Ann; Capasso, Clemente; Supuran, Claudiu T. (literal)

Pagina inizio

• 4389 (literal)

Pagina fine

• 4396 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 24 (literal)

Rivista

• Bioorganic & medicinal chemistry letters (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 8 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 18 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Consiglio Nazionale delle Ricerche (CNR); University of Florence; Griffith University; University of Florence (literal)

Titolo

• Discovery of a new family of carbonic anhydrases in the malaria pathogen Plasmodium falciparum-The eta-carbonic anhydrases (literal)

Abstract

• The genome of the protozoan parasite Plasmodium falciparum, the causative agent of the most lethal type of human malaria, contains a single gene annotated as encoding a carbonic anhydrase (CAs, EC 4.2.1.1) thought to belong to the alpha-class, PfCA. Here we demonstrate the kinetic properties of PfCA for the CO2 hydration reaction, as well as an inhibition study of this enzyme with inorganic and complex anions and other molecules known to interact with zinc proteins, including sulfamide, sulfamic acid, and phenylboronic/arsonic acids, detecting several low micromolar inhibitors. A closer examination of the sequence of this and the CAs from other Plasmodium spp., as well as a phylogenetic analysis, revealed that these protozoa encode for a yet undisclosed, new genetic family of CAs termed the eta-CA class. The main features of the eta-CAs are described in this report. (C) 2014 Elsevier Ltd. All rights reserved. (literal)

Prodotto di

• Istituto di Bioscienze e Biorisorse (IBBR) (Istituto)
• PROF. M. ROSSI: Applicazioni innovative di enzimi e biotrasformazioni (SV.P14.002.001) (Modulo)

Autore CNR

• DANIELA VULLO (Persona)
• CLEMENTE CAPASSO (Unità di personale interno)

Insieme di parole chiave

• Parole chiave di "Discovery of a new family of carbonic anhydrases in the malaria pathogen Plasmodium falciparum-The eta-carbonic anhydrases" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• CLEMENTE CAPASSO (Unità di personale interno)
• DANIELA VULLO (Persona)

Prodotto

• Istituto di Bioscienze e Biorisorse (IBBR) (Istituto)
• PROF. M. ROSSI: Applicazioni innovative di enzimi e biotrasformazioni (SV.P14.002.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Bioorganic & medicinal chemistry letters (Rivista)

Insieme di parole chiave di

• Parole chiave di "Discovery of a new family of carbonic anhydrases in the malaria pathogen Plasmodium falciparum-The eta-carbonic anhydrases" (Insieme di parole chiave)