A transparent organic transistor structure for bidirectional stimulation and recording of primary neurons (Articolo in rivista)

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Label
  • A transparent organic transistor structure for bidirectional stimulation and recording of primary neurons (Articolo in rivista) (literal)
Anno
  • 2013-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1038/NMAT3630 (literal)
Alternative label
  • Valentina Benfenati, Stefano Toffanin, Simone Bonetti, Guido Turatti, Assunta Pistone, Michela Chiappalone, Anna Sagnella, Andrea Stefani, Gianluca Generali, Giampiero Ruani, Davide Saguatti, Roberto Zamboni, Michele Muccini (2013)
    A transparent organic transistor structure for bidirectional stimulation and recording of primary neurons
    in Nature materials (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Valentina Benfenati, Stefano Toffanin, Simone Bonetti, Guido Turatti, Assunta Pistone, Michela Chiappalone, Anna Sagnella, Andrea Stefani, Gianluca Generali, Giampiero Ruani, Davide Saguatti, Roberto Zamboni, Michele Muccini (literal)
Pagina inizio
  • 672 (literal)
Pagina fine
  • 680 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.nature.com/nmat/journal/v12/n7/full/nmat3630.html (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 12 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 9 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 7 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Consiglio Nazionale delle Ricerche (CNR), Istituto per la Sintesi Organica e la Fotoreattività (ISOF), via Gobetti, 101, 40129 Bologna, Italy Consiglio Nazionale delle Ricerche (CNR), Istituto per lo Studio dei Materiali Nanostrutturati (ISMN), via P. Gobetti 101, I-40129 Bologna, Italy E.T.C. s.r.l., via P. Gobetti 101, I-40129 Bologna, Italy Istituto Italiano di Tecnologia (IIT), Department of Neuroscience and Brain Technologies (NBT), Via Morego 30, 16163 Genova, Italy. (literal)
Titolo
  • A transparent organic transistor structure for bidirectional stimulation and recording of primary neurons (literal)
Abstract
  • Real-time stimulation and recording of neural cell bioelectrical activity could provide an unprecedented insight in understanding the functions of the nervous system, and it is crucial for developing advanced in vitro drug screening approaches. Among organic materials, suitable candidates for cell interfacing can be found that combine long-term biocompatibility and mechanical flexibility. Here, we report on transparent organic cell stimulating and sensing transistors (O-CSTs), which provide bidirectional stimulation and recording of primary neurons. We demonstrate that the device enables depolarization and hyperpolarization of the primary neuron membrane potential. The transparency of the device also allows the optical imaging of the modulation of the neuron bioelectrical activity. The maximal amplitude-to-noise ratio of the extracellular recording achieved by the O-CST device exceeds that of a microelectrode array system on the same neuronal preparation by a factor of 16. Our organic cell stimulating and sensing device paves the way to a new generation of devices for stimulation, manipulation and recording of cell bioelectrical activity in vitro and in vivo. (literal)
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