Functionalization of PEGylated Fe3O4 magnetic nanoparticles with tetraphosphonate cavitand for biomedical application (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Functionalization of PEGylated Fe3O4 magnetic nanoparticles with tetraphosphonate cavitand for biomedical application (Articolo in rivista) (literal)

Anno

• 2013-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1039/c3nr02188b (literal)

Alternative label

• Tudisco, C; Bertani, F; Cambria, M T; Sinatra, F; Fantechi, E; Innocenti, C; Sangregorio, C; Dalcanale, E; Condorelli, G G (2013)
  Functionalization of PEGylated Fe3O4 magnetic nanoparticles with tetraphosphonate cavitand for biomedical application
  in Nanoscale (Online)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Tudisco, C; Bertani, F; Cambria, M T; Sinatra, F; Fantechi, E; Innocenti, C; Sangregorio, C; Dalcanale, E; Condorelli, G G (literal)

Pagina inizio

• 11438 (literal)

Pagina fine

• 11446 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 5 (literal)

Rivista

• Nanoscale (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 9 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 23 (literal)

Note

• PubMe (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Dipartimento di Scienze Chimiche, Universita di Catania and INSTM UdR di Catania INSTM UdR di Firenze Univ Florence, Dept Chem, I-50019 Florence, Italy CNR ISTM, I-20133 Milan, Italy (literal)

Titolo

• Functionalization of PEGylated Fe3O4 magnetic nanoparticles with tetraphosphonate cavitand for biomedical application (literal)

Abstract

• In this contribution, Fe3O4 magnetic nanoparticles (MNPs) have been functionalized with a tetraphosphonate cavitand receptor (Tiiii), capable of complexing N-monomethylated species with high selectivity, and polyethylene glycol (PEG) via click-chemistry. The grafting process is based on MNP pre-functionalization with a bifunctional phosphonic linker, 10-undecynylphosphonic acid, anchored on an iron surface through the phosphonic group. The Tiiii cavitand and the PEG modified with azide moieties have then been bonded to the resulting alkyne-functionalized MNPs through a \"click\" reaction. Each reaction step has been monitored by using X-ray photoelectron and FTIR spectroscopies. PEG and Tiiii functionalized MNPs have been able to load N-methyl ammonium salts such as the antitumor drug procarbazine hydrochloride and the neurotransmitter epinephrine hydrochloride and release them as free bases. In addition, the introduction of PEG moieties promoted biocompatibility of functionalized MNPs, thus allowing their use in biological environments. (literal)

Prodotto di

• Institute of molecular science and technologies (ISTM) (Istituto)
• Nanosistemi organizzati di magneti molecolari (PM.P05.012.001) (Modulo)

Autore CNR

• CLAUDIO SANGREGORIO (Unità di personale interno)

Incoming links:

Prodotto

• Institute of molecular science and technologies (ISTM) (Istituto)
• Nanosistemi organizzati di magneti molecolari (PM.P05.012.001) (Modulo)

Autore CNR di

• CLAUDIO SANGREGORIO (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Nanoscale (Rivista)