Intragenic amplification and formation of extrachromosomal small circular DNA (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Intragenic amplification and formation of extrachromosomal small circular DNA (Articolo in rivista) (literal)

Anno

• 2002-01-01T00:00:00+01:00 (literal)

Alternative label

• Autiero M., Camarca A., Ciullo M., Debily M., El Marhomy S., Pasquinelli R., Capasso I, D'Aiuto G., Anzisi A., Piatier-Tonneau D., Guardiola J. (2002)
  Intragenic amplification and formation of extrachromosomal small circular DNA
  in International journal of cancer (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Autiero M., Camarca A., Ciullo M., Debily M., El Marhomy S., Pasquinelli R., Capasso I, D'Aiuto G., Anzisi A., Piatier-Tonneau D., Guardiola J. (literal)

Pagina inizio

• 370 (literal)

Pagina fine

• 377 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 99 (literal)

Rivista

• International journal of cancer (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Titolo

• Intragenic amplification and formation of extrachromosomal small circular DNA (literal)

Abstract

• The PIP gene is expressed in exocrine glands and, in pathologic conditions, in breast cysts and breast cancers exhibiting apocrine features. It is localized on the long arm of chromosome 7, a region frequently alterated in mammary tumors. We previously described an abnormal restriction pattern of the PIP gene in 33% of prostate carcinomas analyzed. Here, we analyze the structure of the PIP gene in primary breast carcinomas. We report that part of the 3' end, including exon3, intron C, two-thirds of exon 4 and a small portion of intron B, is amplified and involved in the formation of extrachromosomal spcDNA molecules in 3/14 (21.4%) breast cancers analyzed. The involvement of a well-defined intragenic region of a gene in the formation of spcDNA appears to be unprecedented. Since spcDNA has been suggested to serve as an enhancer of genetic instability, the PIP gene may be the target of genomic variability processes in breast cancer. (literal)

Prodotto di

• Institute of genetics and biophysics \"Adriano Buzzati Traverso\" (IGB) (Istituto)

Autore CNR

• JOHN GUARDIOLA (Unità di personale interno)
• MARINA CIULLO (Unità di personale esterno)

Incoming links:

Prodotto

• Institute of genetics and biophysics \"Adriano Buzzati Traverso\" (IGB) (Istituto)

Autore CNR di

• MARINA CIULLO (Unità di personale esterno)
• JOHN GUARDIOLA (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• International journal of cancer (Rivista)