Oxidative DNA damage and activation of c-Jun N-terminal kinase pathway in fibroblasts from patients with hereditary spastic paraplegia. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Oxidative DNA damage and activation of c-Jun N-terminal kinase pathway in fibroblasts from patients with hereditary spastic paraplegia. (Articolo in rivista) (literal)

Anno

• 2005-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1007/s10571-005-8501-2 (literal)

Alternative label

• Milano A; Montesano Gesualdi N; Teperino R; Esposito F; Cocozza S; Ungaro P. (2005)
  Oxidative DNA damage and activation of c-Jun N-terminal kinase pathway in fibroblasts from patients with hereditary spastic paraplegia.
  in Cellular and molecular neurobiology
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Milano A; Montesano Gesualdi N; Teperino R; Esposito F; Cocozza S; Ungaro P. (literal)

Pagina inizio

• 1245 (literal)

Pagina fine

• 1254 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 25 (literal)

Rivista

• Cellular and molecular neurobiology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 8 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Dipartimento di Biologia e Patologia Cellulare eMolecolare, Universit`a degli Studi di Napoli \"Federico II,\" Naples, Italy. Dipartimento di Biochimica e Biotecnologie Mediche, Universit`a degli Studi di Napoli \"Federico II,\" Naples, Italy. Istituto di Endocrinologia ed Oncologia Sperimentale \"G. Salvatore,\" Consiglio Nazionale delle Ricerche, Naples, Italy. (literal)

Titolo

• Oxidative DNA damage and activation of c-Jun N-terminal kinase pathway in fibroblasts from patients with hereditary spastic paraplegia. (literal)

Abstract

• 1. Hereditary spastic paraplegia (HSP) is a genetically heterogeneous group of neurodegenerative disorders affecting 1 in 10,000 individuals. The present study was aimed to elucidate the role played by reactive oxygen species (ROS) in the pathogenesis of this disease. 2. To address this question we used 7-11 passaged fibroblasts from HSP patients to measure the extent of DNA damage induced by H2O2 treatment and to evaluate the JNK phosphorylation level after hydrogen peroxide and serum stimuli. 3. The present study demonstrates that HSP cells compared to controls are more sensitive to DNA damages induced by H2O2 treatment, and that JNK phosphorylation levels are increased in HSP fibroblasts compared to controls after hydrogen peroxide and serum stimuli. These results suggest a ROS-mediated pathogenetic mechanism for this disease. (literal)

Prodotto di

• MODELLI ANIMALI PER LO SVILUPPO DI TERAPIE INNOVATIVE DEL DIABETE DI II TIPO (SV.P10.004.001) (Modulo)
• Institute Experimental Endocrinology and Oncology \"Gaetano Salvatore\" (IEOS) (Istituto)

Autore CNR

• PAOLA UNGARO (Persona)

Incoming links:

Autore CNR di

• PAOLA UNGARO (Persona)

Prodotto

• Institute Experimental Endocrinology and Oncology \"Gaetano Salvatore\" (IEOS) (Istituto)
• MODELLI ANIMALI PER LO SVILUPPO DI TERAPIE INNOVATIVE DEL DIABETE DI II TIPO (SV.P10.004.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Cellular and molecular neurobiology (Rivista)