The fine specificity of human T cell lines towards myelin basic protein peptides in southern Italian multiple sclerosis patients. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• The fine specificity of human T cell lines towards myelin basic protein peptides in southern Italian multiple sclerosis patients. (Articolo in rivista) (literal)

Anno

• 2001-01-01T00:00:00+01:00 (literal)

Alternative label

• Montanaro D. 1, Sanna V. 3, Matarese G. 3, Larby B.B. 4, Racioppi L. 1, Carrieri P.B. 2, Bruno R. 2, Davey N.J. 4, Zappacosta S. 1, Fontana S. 3 (2001)
  The fine specificity of human T cell lines towards myelin basic protein peptides in southern Italian multiple sclerosis patients.
  in Clinical and experimental immunology (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Montanaro D. 1, Sanna V. 3, Matarese G. 3, Larby B.B. 4, Racioppi L. 1, Carrieri P.B. 2, Bruno R. 2, Davey N.J. 4, Zappacosta S. 1, Fontana S. 3 (literal)

Pagina inizio

• 288 (literal)

Pagina fine

• 293 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 123 (literal)

Rivista

• Clinical and experimental immunology (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Titolo

• The fine specificity of human T cell lines towards myelin basic protein peptides in southern Italian multiple sclerosis patients. (literal)

Abstract

• We studied the relationship between the HLA specificities associated with multiple sclerosis (MS) susceptibility in southern Italy and the reactivity of the human myelin basic protein (hMBP) immunogenic peptides 84-98 and 143-168, using short-term T-cell lines established from 9 MS patients and from 8 healthy individuals. In our population, DR15 was significantly associated with MS (34.9% in MS versus 13.7% in healthy controls, P < 0.05). This result is in agreement with the association found in northern Europe, but not with data obtained in a population from the island of Sardinia (Italy). In MS patients the frequency of reactive T-cell lines (TCL), tested for fine specificity against the immunodominant hMBP peptides 84-98 and 143-168, was increased for the hMBP 143-168 peptide (P < 0.05) but not for the 84-98 peptide. Although this reactivity was higher in DR15+ MS patients than in DR 15- MS patients, it seemed not to be associated with DR15 specificity in the MS population. Furthermore, there were no significant differences in frequency of reactive TCL to hMBP peptide 84-98 in DR15-positive or DR15-negative MS patients. Consequently, it appears that peptide 84-98, considered as a relevant autoantigen, is not implicated in the pathogenesis of MS in our population from southern Italy. (literal)

Prodotto di

• Institute Experimental Endocrinology and Oncology \"Gaetano Salvatore\" (IEOS) (Istituto)

Autore CNR

• GIUSEPPE MATARESE (Unità di personale interno)
• SILVIA FONTANA (Unità di personale interno)

Incoming links:

Autore CNR di

• GIUSEPPE MATARESE (Unità di personale interno)
• SILVIA FONTANA (Unità di personale interno)

Prodotto

• Institute Experimental Endocrinology and Oncology \"Gaetano Salvatore\" (IEOS) (Istituto)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Clinical and experimental immunology (Rivista)