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Mapping pathological 99mTc-HMPAO uptake in Alzheimer's Disease and Frontal Lobe Dementia with SPECT. (Articolo in rivista)

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Mapping pathological 99mTc-HMPAO uptake in Alzheimer's Disease and Frontal Lobe Dementia with SPECT. (Articolo in rivista) (literal)

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Pagani M., Salmaso D., Ramström C., Jonsson C., Lundqvist R., Thurfjell L., Schnell P.O., Wägner A., Jacobsson H., Larsson S.A. (2001)
Mapping pathological 99mTc-HMPAO uptake in Alzheimer's Disease and Frontal Lobe Dementia with SPECT.
in Dementia and geriatric cognitive disorders; Karger, Basel (Swaziland)
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Pagani M., Salmaso D., Ramström C., Jonsson C., Lundqvist R., Thurfjell L., Schnell P.O., Wägner A., Jacobsson H., Larsson S.A. (literal)

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Implementazione di un atlante cerebrale digitalizzato e standardizzato per mettere in evidenza differenze di flusso tra cervelli normali e patologici. La standardizzazione ha permesso di trovare differenze significative tra aree sottocorticali normalmente difficili da diagnosticare. (literal)

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Seventeen patients with probable Alzheimer Disease (AD), seven patients with Frontal Lobe Dementia (FLD) and nineteen control subjects (NOR) were examined by 99mTc-HMPAO SPECT. Images were standardised in the same 3D space and averaged within each group. After normalisation the three sets of images were analysed in all cerebral lobes, hippocampus, thalamus and basal ganglia. In AD the 99mTc-HMPAO uptake values were significantly reduced, as compared to NOR, in parietal, temporal and insular lobes. In patients with FLD the uptake was reduced in all lobes with the exception of the parietal lobe. The uptake in nucleus caudatus decreased significantly in both AD and FLD as compared to NOR. The uptake in anterior cingulate cortex was significantly reduced in FLD. Subtraction images highlighted all significantly decreased areas. In conclusion, standardising SPECT in a common space and subtracting data from a control group improves the visual interpretation of images. In this study the typical temporo-parietal and fronto-parietal 99mTc-HMPAO uptake reductions were found in AD and FLD respectively. The uptake in nc. caudatus was found to decrease significantly in AD and FLD and the one in anterior cingulate cortex was reduced in FLD. (literal)

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Section of Nuclear Medicine, Radiation Physics, Karolinska Hospital, Stockholm, Sweden Institute of Experimental Medicine, CNR, Rome, Italy Institute of Psychology, CNR, Rome, Italy Department of Geriatrics, Löwenströmska Hospital, Stockholm, Sweden Centre of Image Analysis, Uppsala University, Uppsala, Sweden Department of Neurology, Karolinska Hospital, Stockholm, Sweden Department of Diagnostic Radiology, Karolinska Hospital, Stockholm, Sweden (literal)

Titolo

Mapping pathological 99mTc-HMPAO uptake in Alzheimer's Disease and Frontal Lobe Dementia with SPECT. (literal)

Abstract

Seventeen patients with probable Alzheimer Disease (AD), seven patients with Frontal Lobe Dementia (FLD) and nineteen control subjects (NOR) were examined by 99mTc-HMPAO SPECT. Images were standardised in the same 3D space and averaged within each group. After normalisation the three sets of images were analysed in all cerebral lobes, hippocampus, thalamus and basal ganglia. In AD the 99mTc-HMPAO uptake values were significantly reduced, as compared to NOR, in parietal, temporal and insular lobes. In patients with FLD the uptake was reduced in all lobes with the exception of the parietal lobe. The uptake in nucleus caudatus decreased significantly in both AD and FLD as compared to NOR. The uptake in anterior cingulate cortex was significantly reduced in FLD. Subtraction images highlighted all significantly decreased areas. In conclusion, standardising SPECT in a common space and subtracting data from a control group improves the visual interpretation of images. In this study the typical temporo-parietal and fronto-parietal 99mTc-HMPAO uptake reductions were found in AD and FLD respectively. The uptake in nc. caudatus was found to decrease significantly in AD and FLD and the one in anterior cingulate cortex was reduced in FLD. (literal)

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