Synthesis and biological evaluation of the disulfide form of the glutathione analogue g-(l-glutamyl)-l-cysteinyl-l-aspartyl-l-cysteine? (Articolo in rivista)

Type
Label
  • Synthesis and biological evaluation of the disulfide form of the glutathione analogue g-(l-glutamyl)-l-cysteinyl-l-aspartyl-l-cysteine? (Articolo in rivista) (literal)
Anno
  • 2003-01-01T00:00:00+01:00 (literal)
Alternative label
  • Cacciatore I., Di Stefano A., Dupre S., Morera E., Pinnen F., Spirito A. (2003)
    Synthesis and biological evaluation of the disulfide form of the glutathione analogue g-(l-glutamyl)-l-cysteinyl-l-aspartyl-l-cysteine?
    in Bioorganic chemistry (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Cacciatore I., Di Stefano A., Dupre S., Morera E., Pinnen F., Spirito A. (literal)
Pagina inizio
  • 107 (literal)
Pagina fine
  • 119 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 31(2) (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Titolo
  • Synthesis and biological evaluation of the disulfide form of the glutathione analogue g-(l-glutamyl)-l-cysteinyl-l-aspartyl-l-cysteine? (literal)
Abstract
  • By using the chain to chain mode of cyclization the title glutathione analogue y-Glu-Cys-Asp-Cys (4), containing the 11-membered disulide ring –Cys-Asp-Cys- replacing the native -Cys-Gly fragment, has been synthesized and characterized together with its reduced dithiol form y-Glu-Cys-Asp-Cys (5). The activity of (4) with y-glutamyl-transferase and glutathione reductase has been evaluated and compared with those of the two conformationally restricted glutathione analogues (2) and (3) previously reported. (literal)
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