Different in vitro activity of flurbiprofen and its enantiomers on human articular cartilage (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Different in vitro activity of flurbiprofen and its enantiomers on human articular cartilage (Articolo in rivista) (literal)

Anno

• 2003-01-01T00:00:00+01:00 (literal)

Alternative label

• PANICO A. M., CARDILE V., GENTILE B., RONSISVALLE G., SCOTO G.M., PARENTI C ., MORRONE R., NICOLOSI G. (2003)
  Different in vitro activity of flurbiprofen and its enantiomers on human articular cartilage
  in Il Farmaco (Pavia)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• PANICO A. M., CARDILE V., GENTILE B., RONSISVALLE G., SCOTO G.M., PARENTI C ., MORRONE R., NICOLOSI G. (literal)

Pagina inizio

• 1339 (literal)

Pagina fine

• 1344 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 58 (literal)

Rivista

• ?Il ?Farmaco (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Titolo

• Different in vitro activity of flurbiprofen and its enantiomers on human articular cartilage (literal)

Abstract

• The 2-arylpropionic acid derivatives or \"profens\" are an important group of non-steroidal anti-inflammatory drugs (NSAIDs) that have been used for the symptomatic treatment of various forms of arthritis. These compounds are chiral and the majority of them are still marketed as racemate although it is know that the S form is the principal effective in the COX inhibition. However, recent findings suggest that certain pharmacological effect of 2-arylpropionic acids cannot be attributed exclusively to the S (+) enantiomer. To obtain further insights into the pharmacological effect of profen, the present study investigated the influence of racemic and pure enantiomers, of flurbiprofen on the production of nitric oxide (NO) and glycosaminoglycans (GAGs), key molecules involved in cartilage destruction. The culture of human articular cartilage stimulated by interleukin -betaƒzƒnƒnwich play an important role in the degradatation of cartilage, has been established, as a profit experimental model, for reproducing the mechanisms involved in the pathophysiology of arthritic diseases. Our results show that mainly S (+) flurbiprofen decrease, at therapeutic concentrations, the IL-1-beta induced cartilage destruction. (literal)

Prodotto di

• Institute of biomolecular chemistry (ICB) (Istituto)

Autore CNR

• GIOVANNI NICOLOSI (Persona)
• RAFFAELE MORRONE (Persona)

Incoming links:

Prodotto

• Institute of biomolecular chemistry (ICB) (Istituto)

Autore CNR di

• GIOVANNI NICOLOSI (Persona)
• RAFFAELE MORRONE (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• ?Il ?Farmaco (Rivista)