MARIE CURIE FOIE GRAS RISE (DSB.AD007.142)
Thematic area
Project area
Biomedicina Traslazionale (DSB.AD007)Structure responsible for the research project
Institute of clinical physiology (IFC)
Project manager
AMALIA GASTALDELLI
Phone number: 050 3152680
Email: amalia@ifc.cnr.it
Abstract
mtFOIE GRAS (Foie Gras being French for "fat liver") proposes to address the pressing need for non-invasive, accurate, rapid assessment of NAFLD/NASH stages, before and after intervention, through the development of biomarkers and innovative tools to follow mitochondrial (mt) dysfunction, a central mediator of fatty liver disease pathogenesis. This promising R&D strategy will also bring new knowledge about the disease mechanisms and improved understanding of the pathogenic process and disease drivers.
To that end, mtFOIE GRAS envisages a training-through-work plan that brings together an intersectoral, multidisciplinary team of researchers and technicians experts in their fields, from basic to translational research, clinical practice, technology commercialization and public advocacy. Together with several PhD students, the team will share expertises and work synergistically along the value creation chain to address the unmet medical need of more informative NAFLD assessment. In the process, mtFOIE GRAS will endow the involved staff with excellent scientific knowledge and transferable skills while building and strengthening intersectoral cooperation among partners, thus contributin
Goals
The main scientific goal of mtFOIE GRAS is to identify innovative biomarkers and develop non-invasive methodologies for mitochondrial profiling in the context of NAFLD/NASH. As part of the process, novel therapeutic strategies will be envisaged. To this end, mtFOIE GRAS will create an inter-sectorial network to encourage synergies between the partners, along academic and industrial research,
Start date of activity
01/01/2017
Keywords
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Last update: 20/05/2024