Consiglio Nazionale delle Ricerche

Tipo di prodottoArticolo in rivista
TitoloGenetically-dependent modulation of serotonergic inactivation in the human prefrontal cortex.
Anno di pubblicazione2008
Formato
  • Elettronico
  • Cartaceo
Autore/iPassamonti L; Cerasa A; Gioia MC; Magariello A; Muglia M; Quattrone A; Fera F
Affiliazioni autoria Medical Research Council, Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge, CB2 7EF, UK b National Research Council, Institute of Neurological Sciences, Piano Lago di Mangone (CS), 87050, Italy c Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 2QQ, UK d Medical Research Council Behavioural and Clinical Neurosciences Institute, Downing Site, Cambridge, CB2 3E, UK
Autori CNR e affiliazioni
  • MARIA CECILIA GIOIA
  • ALDO QUATTRONE
  • FRANCESCO FERA
  • ANGELA MAGARIELLO
  • LUCA PASSAMONTI
  • ANTONIO CERASA
  • MARIA MUGLIA
Lingua/e
  • inglese
AbstractPrevious research suggests that genetic variations regulating serotonergic neurotransmission mediate individual differences in the neural network underlying impulsive and aggressive behaviour. Although with conflicting findings, the monoamine oxidase-A (MAOA) and the serotonin transporter (5HTT) gene polymorphisms have been associated with an increased risk to develop impulsive and aggressive behaviour. Double knock-out mice studies have also demonstrated that MAOA and 5HTT genes strongly interact in the metabolic pathway leading to the serotonergic inactivation; however, their potential interactive effect in human brain remains uninvestigated. We used blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging (fMRI) to assess the independent and interactive effects of both MAOA and 5HTT polymorphisms on the brain activity elicited by a response inhibition task in healthy volunteers. Multivariate analysis demonstrated an individual effect of both MAOA and 5HTT polymorphisms and a strong allele-allele interaction in the anterior cingulate cortex (ACC), a key region implicated in cognitive control and in the pathophysiology of impulsive and aggressive behaviour. These findings suggest that the MAOAx5HTT allelic interaction exerts a significant modulation on the BOLD response associated with response inhibition and contribute to validate haplotype models as useful tools for a better understanding of the neurobiology underlying complex cognitive functions.
Lingua abstractinglese
Altro abstract-
Lingua altro abstract-
Pagine da1264
Pagine a1273
Pagine totali10
RivistaNeuroImage (Orlando Fla., Print)
Attiva dal 1992
Editore: Academic Press, - Orlando, FL
Paese di pubblicazione: Stati Uniti d'America
Lingua: inglese
ISSN: 1053-8119
Titolo chiave: NeuroImage (Orlando Fla., Print)
Titolo proprio: NeuroImage. (Orlando Fla., Print)
Titolo abbreviato: NeuroImage (Orlando Fla., Print)
Titolo alternativo: Neuro image (Orlando Fla., Print)
Numero volume della rivista40
Fascicolo della rivista3
DOI10.1016/j.neuroimage.2007.12.028
Verificato da refereeSì: Internazionale
Stato della pubblicazione-
Indicizzazione (in banche dati controllate)
  • PubMed (Codice:18261931)
  • ISI Web of Science (WOS) (Codice:000254728200026)
Parole chiaveImpulsivity, MAOA, 5HTT, Response inhibition, fMRI
Link (URL, URI)http://www.sciencedirect.com/science/article/pii/S1053811907011421
Titolo parallelo-
Licenza-
Scadenza embargo-
Data di accettazione-
Note/Altre informazioni-
Strutture CNR
  • ISN — Istituto di scienze neurologiche
Moduli/Attività/Sottoprogetti CNR
  • ME.P06.017.001 : Imaging funzionale delle malattie ereditarie del sistema nervoso
Progetti Europei-
Allegati
Genetically dependent modulation of serotonergic inactivation in the human prefrontal cortex. (documento privato )
Descrizione: .pdf del manoscritto
Tipo documento: application/pdf

Dati storici
I dati storici non sono modificabili, sono stati ereditati da altri sistemi (es. Gestione Istituti, PUMA, ...) e hanno solo valore storico.
Area disciplinareNeurosciences & Behavior
Area valutazione CIVRScienze mediche
Rivista ISINEUROIMAGE [10486J0]