Consiglio Nazionale delle Ricerche

Tipo di prodottoArticolo in rivista
TitoloFunctional changes in the activity of cerebellum and frontostriatal regions during externally and internally timed movement in Parkinson's disease.
Anno di pubblicazione2006
Formato-
Autore/iCerasa A, Hagberg GE, Peppe A, Bianciardi M, Gioia MC, Costa A, Castriota-Scanderbeg A, Caltagirone C, Sabatini U.
Affiliazioni autoriInstitute of Neurological Sciences, National Research Council, Piano Lago di Mangone, 87050 Cosenza, Italy.
Autori CNR e affiliazioni
  • ANTONIO CERASA
  • MARIA CECILIA GIOIA
Lingua/e-
AbstractWe used fMRI to investigate the neurofunctional basis of externally and internally timed movements in Parkinson's disease (PD) patients. Ten PD patients whose medication had been withheld for at least 18h and 11 age- and sex-matched healthy controls were scanned while performing continuation paradigm with a visual metronome. Compared with the controls, PD patients displayed an intact capability to store and reproduce movement frequencies but with a significantly increased movement latencies. No differences in BOLD response were found in both groups when comparing the continuation with the preceding synchronization phase and viceversa, except for activity in visually related regions. Relative to healthy controls during the synchronization phase, PD patients exhibited an overall signal increase in the cerebellum and frontostriatal circuit (putamen, SMA and thalamus) activity together with specific brain areas (right inferior frontal gyrus and insula cortex) that are also implicated in primary timekeeper processes. By contrast, in the continuation phase the only neural network involved to a greater extent by the PD group was the cerebello-thalamic pathway. The lack of neurofunctional differences between the two timing phases suggests that rhythmic externally and internally guided movements engage similar neural networks in PD and matched healthy controls. Moreover, between-group comparison indicates that PD patients OFF medication may compensate for their basal ganglia-cortical loop's dysfunction using different motor pathways involving cerebellum and basal ganglia relays during the two phases of rhythmic movement.
Lingua abstract-
Altro abstract-
Lingua altro abstract-
Pagine da259
Pagine a269
Pagine totali-
RivistaBrain research bulletin
Attiva dal 1976
Editore: ANKHO International Inc., - Phoenix, N.Y.
Paese di pubblicazione: Stati Uniti d'America
Lingua: inglese
ISSN: 0361-9230
Titolo chiave: Brain research bulletin
Titolo proprio: Brain research bulletin.
Titolo abbreviato: Brain res. bull.
Numero volume della rivista71
Fascicolo della rivista-
DOI-
Verificato da referee-
Stato della pubblicazione-
Indicizzazione (in banche dati controllate)-
Parole chiavefMRI, Parkinson’s disease, Motor activity
Link (URL, URI)-
Titolo parallelo-
Licenza-
Scadenza embargo-
Data di accettazione-
Note/Altre informazioni-
Strutture CNR
  • ISN — Istituto di scienze neurologiche
Moduli/Attività/Sottoprogetti CNR
  • ME.P06.017.001 : Imaging funzionale delle malattie ereditarie del sistema nervoso
Progetti Europei-
Allegati

Dati storici
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Area disciplinareNeurology
Area valutazione CIVRScienze mediche
Rivista ISIBRAIN RESEARCH BULLETIN [21367J0]
NoteInstitute of Neurological Sciences, National Research Council, Piano Lago di Mangone, Cosenza 87050, Italy. Neuroimaging Laboratory, Fondazione Santa Lucia, IRCCS, 00179 Rome, Italy.