Consiglio Nazionale delle Ricerche

Tipo di prodottoArticolo in rivista
TitoloNeocortical modulation of the amygdala response to fearful stimuli.
Anno di pubblicazione2003
Formato-
Autore/iHariri AR 1, Mattay VS 1, Tessitore A 1, Fera F 1-2, Weinberger DR.1
Affiliazioni autori-
Autori CNR e affiliazioni
  • FRANCESCO FERA
Lingua/e-
AbstractBACKGROUND: The cortical circuitry involved in conscious cognitive processes and the subcortical circuitry involved in fear responses have been extensively studied with neuroimaging, but their interactions remain largely unexplored. A recent functional magnetic resonance imaging (fMRI) study demonstrated that the engagement of the right prefrontal cortex during the cognitive evaluation of angry and fearful facial expressions is associated with an attenuation of the response of the amygdala to these same stimuli, providing evidence for a functional neural network for emotional regulation. METHODS: In the current study, we have explored the generalizability of this functional network by using threatening and fearful non-face stimuli derived from the International Affective Picture System (IAPS), as well as the influence of this network on peripheral autonomic responses. RESULTS: Similar to the earlier findings with facial expressions, blood oxygen level dependent fMRI revealed that whereas perceptual processing of IAPS stimuli was associated with a bilateral amygdala response, cognitive evaluation of these same stimuli was associated with attenuation of this amygdala response and a correlated increase in response of the right prefrontal cortex and the anterior cingulate cortex. Moreover, this pattern was reflected in changes in skin conductance. CONCLUSIONS: The current results further implicate the importance of neocortical regions, including the prefrontal and anterior cingulate cortices, in regulating emotional responses mediated by the amygdala through conscious evaluation and appraisal.
Lingua abstract-
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Lingua altro abstract-
Pagine da494
Pagine a501
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RivistaBiological psychiatry (1969)
Attiva dal 1969
Editore: Elsevier [etc.] - [New York]
Paese di pubblicazione: Stati Uniti d'America
Lingua: inglese
ISSN: 0006-3223
Titolo chiave: Biological psychiatry (1969)
Titolo proprio: Biological psychiatry. (1969)
Titolo abbreviato: Biol. psychiatry (1969)
Titolo alternativo: Biol psychiatry (1969)
Numero volume della rivista53
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DOI-
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Note/Altre informazioni-
Strutture CNR
  • ISN — Istituto di scienze neurologiche
Moduli/Attività/Sottoprogetti CNR-
Progetti Europei-
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Rivista ISIBIOLOGICAL PSYCHIATRY [20174J0]