Consiglio Nazionale delle Ricerche

Tipo di prodottoArticolo in rivista
TitoloLiving optical random neural network with three dimensional tumor spheroids for cancer morphodynamics
Anno di pubblicazione2020
FormatoElettronico
Autore/iPierangeli D.; Palmieri V.; Marcucci G.; Moriconi C.; Perini G.; De Spirito M.; Papi M.; Conti C.
Affiliazioni autoriInstitute for Complex Systems, National Research Council (ISC-CNR), Rome, 00185, Institute for Complex Systems, National Research Council (ISC-CNR), 00185, Rome, Italy, Italy; Institute for Complex Systems, National Research Council (ISC-CNR), Rome, 00185, Institute for Complex Systems, National Research Council (ISC-CNR), 00185, Rome, Italy, Italy; Department of Physics, University Sapienza, Rome, 00185, Department of Physics, University Sapienza, 00185, Rome, Italy, Italy; Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, 00168, Fondazione Policlinico Universitario A. Gemelli, IRCCS, 00168, Rome, Italy, , Italy; Institute of Physics, University Cattolica del Sacro Cuore, Rome, 00168, Institute of Physics, University Cattolica del Sacro Cuore, 00168, Rome, Italy, , Italy; Pathology and Cell Biology, Columbia University Irving Medical Center-New York Presbyterian Hospital, New York, NY, 10032, Pathology and Cell Biology, Columbia University Irving Medical Center-New York Presbyterian Hospital, New York, NY, 10032, USA, United States; Pathology and Cell Biology, Columbia University Irving Medical Center-New York Presbyterian Hospital, New York, NY, 10032, Pathology and Cell Biology, Columbia University Irving Medical Center-New York Presbyterian Hospital, New York, NY, 10032, USA, United States; Pathology and Cell Biology, Columbia University Irving Medical Center-New York Presbyterian Hospital, New York, NY, 10032, Pathology and Cell Biology, Columbia University Irving Medical Center-New York Presbyterian Hospital, New York, NY, 10032, USA, United States
Autori CNR e affiliazioni
  • GIULIA MARCUCCI
  • DAVIDE PIERANGELI
  • VALENTINA PALMIERI
  • CLAUDIO CONTI
Lingua/e
  • inglese
AbstractOptical neural networks process information at the speed of light and are energetically efficient. Photonic artificial intelligence allows speech recognition, image classification, and Ising machines. Modern machine learning paradigms, as extreme learning machines, reveal that disordered and biological materials may realize optical neural networks with thousands of nodes trained only at the input and at the readout. May we use living matter for machine learning? Here, we employ living three-dimensional tumor brain models to demonstrate a random optical learning machine (ROM) for the investigation of glioblastoma. The tumor spheroid act as a computational reservoir. The ROM detects cancer morphodynamics by laser-induced hyperthermia, quantifies chemotherapy, and cell metabolism. The ROM is a sensitive noninvasive smart probe for cytotoxicity assay and enables real-time investigation of tumor dynamics. We hence design and demonstrate a novel bio-hardware for optical computing and the study of light/complex matter interaction.
Lingua abstractinglese
Altro abstract-
Lingua altro abstract-
Pagine da1
Pagine a10
Pagine totali10
RivistaCommunications physics
Attiva dal 2018
Editore: Springer Nature - London
Paese di pubblicazione: Regno Unito
Lingua: inglese
ISSN: 2399-3650
Titolo chiave: Communications physics
Titolo proprio: Communications physics
Titolo abbreviato: Commun. phys.
Numero volume della rivista3
Fascicolo della rivista1
DOI10.1038/s42005-020-00428-9
Verificato da referee-
Stato della pubblicazionePublished version
Indicizzazione (in banche dati controllate)
  • Scopus (Codice:2-s2.0-85091033776)
  • ISI Web of Science (WOS) (Codice:000573080200002)
Parole chiaveBrain models, Chemotherapy, Diseases, Machine learning, Metabolism, Optical data processing, Speech recognitionTumors
Link (URL, URI)https://www.nature.com/articles/s42005-020-00428-9
Titolo parallelo-
Licenza-
Scadenza embargo-
Data di accettazione11/08/2020
Note/Altre informazioniFunding PRIN PELM (20177PSCKT)
Strutture CNR
  • ISC — Istituto dei sistemi complessi
Moduli/Attività/Sottoprogetti CNR-
Progetti Europei-
Allegati