Consiglio Nazionale delle Ricerche

Tipo di prodottoArticolo in rivista
TitoloThe neurobiology of human aggressive behavior: Neuroimaging, genetic, and neurochemical aspects
Anno di pubblicazione2021
Formato
  • Elettronico
  • Cartaceo
Autore/iCupaioli F.A.; Zucca F.A.; Caporale C.; Lesch K.P.; Passamonti L.; Zecca L.
Affiliazioni autori[Cupaioli, Francesca A.; Zucca, Fabio A.; Zecca, Luigi] Institute of Biomedical Technologies, National Research Council of Italy, Segrate (Milan) Italy; [Caporale, Cinzia] Institute of Biomedical Technologies, National Research Council of Italy, Unit of Rome, Rome, Italy; [Caporale, Cinzia] Interdepartmental Center for Research Ethics and Integrity, National Research Council of Italy, Rome, Italy; [Lesch, Klaus-Peter] Division of Molecular Psychiatry, Center of Mental Health, University of Würzburg, Würzburg, Germany; [Passamonti, Luca] Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK; [Passamonti, Luca] Institute of Bioimaging and Molecular Physiology, National Research Council of Italy, Segrate (Milan), Italy; [Passamonti, Luca] IRCCS San Camillo Hospital, Venice, Italy. Zecca, L (reprint author), Institute of Biomedical Technologies, National Research Council of Italy, Via Cervi 93, 20090 Segrate (Milan), Italy; e-mail: luigi.zecca@itb.cnr.it Passamonti, L (reprint author), Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0SZ, UK; e-mail: lp337@medschl.cam.ac.uk Lesch, KP (reprint author), Division of Molecular Psychiatry, Center of Mental Health, University of Würzburg, Würzburg, Germany; e-mail: kplesch@mail.uni-wuerzburg.de
Autori CNR e affiliazioni
  • LUIGI ZECCA
  • FABIO ANDREA ZUCCA
  • LUCA PASSAMONTI
  • CINZIA CAPORALE
  • FRANCESCA ANNA CUPAIOLI
Lingua/e
  • inglese
AbstractIn modern societies, there is a strive to improve the quality of life related to risk of crimes which inevitably requires a better understanding of brain determinants and mediators of aggression. Neurobiology provides powerful tools to achieve this end. Pre-clinical and clinical studies show that changes in regional volumes, metabolism-function and connectivity within specific neural networks are related to aggression. Subregions of prefrontal cortex, insula, amygdala, basal ganglia and hippocampus play a major role within these circuits and have been consistently implicated in biology of aggression. Genetic variations in proteins regulating the synthesis, degradation, and transport of serotonin and dopamine as well as their signal transduction have been found to mediate behavioral variability observed in aggression. Gene-gene and gene-environment interactions represent additional important risk factors for aggressiveness. Considering the social burden of pathological forms of aggression, more basic and translational studies should be conducted to accelerate applications to clinical practice, justice courts, and policy making.
Lingua abstractinglese
Altro abstract-
Lingua altro abstract-
Pagine da110059
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Pagine totali-
RivistaProgress in neuro-psychopharmacology & biological psychiatry
Attiva dal 1982
Editore: Pergamon - New York
Paese di pubblicazione: Regno Unito
Lingua: inglese
ISSN: 0278-5846
Titolo chiave: Progress in neuro-psychopharmacology & biological psychiatry
Titolo proprio: Progress in neuro-psychopharmacology & biological psychiatry.
Titolo abbreviato: Prog. neuro-psychopharmacol. biol. psychiatry
Titolo alternativo: PNP & BP journal
Numero volume della rivista106
Fascicolo della rivista-
DOI10.1016/j.pnpbp.2020.110059
Verificato da refereeSì: Internazionale
Stato della pubblicazionePublished version
Indicizzazione (in banche dati controllate)
  • ISI Web of Science (WOS) (Codice:000600694200003)
  • PubMed (Codice:32822763)
Parole chiaveaggression, imaging of aggressive brain, brain regions of aggression, dopamine and serotonin in aggression, genetics of aggression
Link (URL, URI)-
Titolo parallelo-
Licenza-
Scadenza embargo-
Data di accettazione-
Note/Altre informazioniPublication date: 2021 Mar 2. Epub: 2020 Aug 19.
Strutture CNR
  • IBFM — Istituto di bioimmagini e fisiologia molecolare
  • ITB — Istituto di tecnologie biomediche
Moduli/Attività/Sottoprogetti CNR-
Progetti Europei-
Allegati