Consiglio Nazionale delle Ricerche

Tipo di prodottoArticolo in rivista
TitoloApomorphine-induced reorganization of striato-frontal connectivity in patients with tremor-dominant Parkinson's disease
Anno di pubblicazione2019
Formato-
Autore/iSalvatore Nigro* a, Cécile Bordier* b,i, Antonio Cerasa c, Rita Nisticò c, Giuseppe Olivadese c, Basilio Vescio d , Maria Giovanna Bianco e, Antonino Fiorillo e, Gaetano Barbagallo f, Marianna Crasà c, Andrea Quattrone f, Maurizio Morelli f, Gennarina Arabia f, Antonio Augimeri d, Carlo Nicolini b, Angelo Bifone b,g, Aldo Quattrone c,h
Affiliazioni autoria. Department of Experimental and Clinical Medicine, Magna Graecia University, Catanzaro, Italy b. Center for Neuroscience and Cognitive Systems, Istituto Italiano di Tecnologia, Rovereto, TN, Italy c. Institute of Molecular Bioimaging and Physiology, National Research Council, Catanzaro, Italy d. Biotecnomed S.C.aR.L, Catanzaro, Italy e. Department of Health Sciences, Magna Graecia University, Catanzaro, Italy f. Institute of Neurology, Department of Medical and Surgical Sciences, University "Magna Graecia", Catanzaro, Italy g. Department of Molecular Biotechnologies and Health Sciences, University of Torino, Torino, Italy h. Neuroscience Centre, University "Magna Graecia", Catanzaro, Italy i. In-vivo Imaging and Functions core facility, Lille University and Lille University Medical Centre, Lille, France
Autori CNR e affiliazioni
  • GIUSEPPE OLIVADESE
  • ANTONIO CERASA
  • RITA NISTICO'
Lingua/e
  • inglese
AbstractIntroduction: Apomorphine is a dopamine agonist used in Parkinson's disease (PD), which matches levodopa in terms of the magnitude of effect on the cardinal motor features, such as tremor and bradykinesia. The beneficial effect of this treatment on PD patients with tremor-dominant has widely been demonstrated, although the underlying neural correlates are unknown. We sought to examine the effects of apomorphine on topological characteristics of resting-state functional connectivity networks in tremor-dominant PD (tdPD) patients. Methods: Sixteen tdPD patients were examined using a combined electromyography-functional magnetic resonance imaging approach. Patients were scanned twice following either placebo (subcutaneous injection of 1 mL saline solution) or 1 mg of apomorphine injection. Graph analysis methods were employed to investigate the modular organization of functional connectivity networks before and after drug treatment. Results: After injection of apomorphine, evident reduction of tremor symptoms was mirrored by a significant increase in overall connectivity strength and reorganization of the modular structure of the basal ganglia and of the fronto-striatal module. Moreover, we found an increase in the centrality of motor and premotor regions. No differences were found between pre- and post-placebo sessions. Conclusion: These results provide new evidence about the effects of apomorphine at a large-scale neural network level showing that drug treatment modifies the brain functional organization of tdPD, increasing the overall resting-state functional connectivity strength, the segregation of striato-frontal regions and the integrative role of motor areas.
Lingua abstractinglese
Altro abstract-
Lingua altro abstract-
Pagine da14
Pagine a20
Pagine totali7
RivistaParkinsonism & related disorders
Attiva dal 1995
Editore: Elsevier Science, - Oxford
Paese di pubblicazione: Regno Unito
Lingua: inglese
ISSN: 1353-8020
Titolo chiave: Parkinsonism & related disorders
Titolo proprio: Parkinsonism & related disorders.
Titolo abbreviato: Parkinsonism relat. disord.
Titolo alternativo: Parkinsonism and related disorders
Numero volume della rivista67
Fascicolo della rivista-
DOI10.1016/j.parkreldis.2019.09.006
Verificato da referee-
Stato della pubblicazionePublished version
Indicizzazione (in banche dati controllate)
  • Scopus (Codice:2-s2.0-85072298317)
  • PubMed (Codice:31621599)
Parole chiaveTremor-dominant Parkinson's disease, Apomorphine, Resting-state, fMRI Graph theory, Community detection
Link (URL, URI)http://www.scopus.com/inward/record.url?eid=2-s2.0-85072298317&partnerID=q2rCbXpz
Titolo parallelo-
Licenza-
Scadenza embargo-
Data di accettazione07/09/2019
Note/Altre informazioni* These authors equally contribute to this work.
Strutture CNR
  • IBFM — Istituto di bioimmagini e fisiologia molecolare
Moduli/Attività/Sottoprogetti CNR
  • DSB.AD004.039.001 : NEUROIMAGING CLINICO DEI DISORDINI NEURODEGENERATIVI DEL MOVIMENTO
Progetti Europei-
Allegati