Consiglio Nazionale delle Ricerche

Tipo di prodottoArticolo in rivista
TitoloAcoustic stimulation can induce a selective neural network response mediated by piezoelectric nanoparticles
Anno di pubblicazione2018
Formato-
Autore/iRojas C, Tedesco M, Massobrio P, Marino A, Ciofani G, Martinoia S, Raiteri R
Affiliazioni autoriDepartment of Informatics Bioengineering Robotics, and System Engineering, University of Genova, Via Opera Pia 13, Genova, 16145, , Italy; Smart Bio-Interfaces, Istituto Italiano di Tecnologia, Viale Rinaldo Piaggio 34, Pontedera, 56025, , Italy; Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Corso Duca degli Abruzzi 24, Torino, 10129, , Italy; National Council of Research (CNR), IBF Institute, via de Marini 6, Genova, 16149, , Italy
Autori CNR e affiliazioni
  • SERGIO MARTINOIA
  • ROBERTO RAITERI
Lingua/e
  • inglese
AbstractObjective. We aim to develop a novel non-invasive or minimally invasive method for neural stimulation to be applied in the study and treatment of brain (dys)functions and neurological disorders. Approach. We investigate the electrophysiological response of in vitro neuronal networks when subjected to low-intensity pulsed acoustic stimulation, mediated by piezoelectric nanoparticles adsorbed on the neuronal membrane. Main results. We show that the presence of piezoelectric barium titanate nanoparticles induces, in a reproducible way, an increase in network activity when excited by stationary ultrasound waves in the MHz regime. Such a response can be fully recovered when switching the ultrasound pulse off, depending on the generated pressure field amplitude, whilst it is insensitive to the duration of the ultrasound pulse in the range 0.5 s-1.5 s. We demonstrate that the presence of piezoelectric nanoparticles is necessary, and when applying the same acoustic stimulation to neuronal cultures without nanoparticles or with non-piezoelectric nanoparticles with the same size distribution, no network response is observed. Significance. We believe that our results open up an extremely interesting approach when coupled with suitable functionalization strategies of the nanoparticles in order to address specific neurons and/or brain areas and applied in vivo, thus enabling remote, non-invasive, and highly selective modulation of the activity of neuronal subpopulations of the central nervous system of mammalians.
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RivistaJournal of neural engineering (Print)
Attiva dal 2004
Editore: Institute of Physics Publishing, - Bristol
Paese di pubblicazione: Regno Unito
Lingua: inglese
ISSN: 1741-2560
Titolo chiave: Journal of neural engineering (Print)
Titolo proprio: Journal of neural engineering. (Print)
Numero volume della rivista15
Fascicolo della rivista3
DOI10.1088/1741-2552/aaa140
Verificato da referee-
Stato della pubblicazionePublished version
Indicizzazione (in banche dati controllate)
  • Scopus (Codice:2-s2.0-85045948627)
  • ISI Web of Science (WOS) (Codice:000429366500001)
Parole chiaveultrasound neuromodulation; barium titanate nanoparticles; microelectrode array
Link (URL, URI)http://www.scopus.com/inward/record.url?eid=2-s2.0-85045948627&partnerID=q2rCbXpz
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Note/Altre informazioni-
Strutture CNR
  • IBF — Istituto di biofisica
Moduli/Attività/Sottoprogetti CNR
  • DFM.AD004.022.001 : Meccanismi molecolari del trasporto ionico transmembrana. Canalopatie e proposte terapeutiche
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