Consiglio Nazionale delle Ricerche

Tipo di prodottoArticolo in rivista
TitoloExploiting botulinum neurotoxins for the study of brain physiology and pathology
Anno di pubblicazione2018
Formato
  • Elettronico
  • Cartaceo
Autore/iCaleo, M.; Restani, L.
Affiliazioni autoriCNR Neuroscience Institute, via G. Moruzzi 1, Pisa, 56124, Italy
Autori CNR e affiliazioni
  • MATTEO CALEO
  • LAURA RESTANI
Lingua/e
  • inglese
AbstractBotulinum neurotoxins are metalloproteases that specifically cleave N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins in synaptic terminals, resulting in a potent inhibition of vesicle fusion and transmitter release. The family comprises different serotypes (BoNT/A to BoNT/G). The natural target of these toxins is represented by the neuromuscular junction, where BoNTs block acetylcholine release. In this review, we describe the actions of botulinum toxins after direct delivery to the central nervous system (CNS), where BoNTs block exocytosis of several transmitters, with near-complete silencing of neural networks. The use of clostridial neurotoxins in the CNS has allowed us to investigate specifically the role of synaptic activity in different physiological and pathological processes. The silencing properties of BoNTs can be exploited for therapeutic purposes, for example to counteract pathological hyperactivity and seizures in epileptogenic brain foci, or to investigate the role of activity in degenerative diseases like prion disease. Altogether, clostridial neurotoxins and their derivatives hold promise as powerful tools for both the basic understanding of brain function and the dissection and treatment of activity-dependent pathogenic pathways.
Lingua abstractinglese
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Pagine da-
Pagine a-
Pagine totali11
RivistaToxins (Basel)
Attiva dal 2009
Editore: MDPI - Basel
Lingua: inglese
ISSN: 2072-6651
Titolo chiave: Toxins (Basel)
Titolo proprio: Toxins. (Basel)
Titolo abbreviato: Toxins (Basel)
Numero volume della rivista10
Fascicolo della rivista5
DOI10.3390/toxins10050175
Verificato da refereeSì: Internazionale
Stato della pubblicazionePublished version
Indicizzazione (in banche dati controllate)
  • ISI Web of Science (WOS) (Codice:000435198800006)
  • Scopus (Codice:2-s2.0-85047261781)
Parole chiavesynaptic transmission, SNAP-25, epilepsy, Parkinson's disease, neurotransmission blockade, electrical activity, prion disease
Link (URL, URI)https://www.ncbi.nlm.nih.gov/pubmed/29693600
Titolo parallelo-
Licenza-
Scadenza embargo-
Data di accettazione23/04/2018
Note/Altre informazioniFinancial support from AIRC (Italian Association for Cancer Research) grant #IG18925, Regione Toscana (RONDA Project, "Programma Attuativo Regionale" financed by FAS--now FSC), CNR InterOmics project, and CNR NanoMax project
Strutture CNR
  • IN — Istituto di neuroscienze
Moduli/Attività/Sottoprogetti CNR-
Progetti Europei-
Allegati
Articolo pubblicato
Tipo documento: application/pdf