Consiglio Nazionale delle Ricerche

Tipo di prodottoArticolo in rivista
TitoloEvidence for a trigeminal mesencephalic-hypoglossal nuclei loop involved in controlling vibrissae movements in the rat
Anno di pubblicazione2016
Autore/iOmbretta Mameli · Marcello Alessandro Caria · Rosalia Pellitteri · Antonella Russo · Salvatore Saccone · Stefania Stanzani
Affiliazioni autoriHuman Physiology Division, Department of Clinical and Experimental Medicine, University of Sassari, viale San Pietro 8, 07100 Sassari, Italy Institute of Neurological Sciences, National Research Council, Section of Catania, 95125 Catania, Italy Department of Biomedical Sciences and Biotechnology, Catania University, 95125 Catania, Italy Department of Biological, Geological and Environmental Sciences, Catania University, 95100 Catania, Italy
Autori CNR e affiliazioni
  • inglese
AbstractPrevious studies performed in rats showed that the whisker-pad motor innervation involves not only the facial nerve, but also some hypoglossal neurons whose axons travel within the trigeminal infraorbital nerve (ION) and target the extrinsic muscles surrounding the whisker-pad macrovibrissae. Furthermore, the electrical stimulation of the ION induced an increase in the EMG activity of these muscles, while the hypoglossal nucleus stimulation elicited evoked potentials and single motor unit responses. However, the existence of a neural network able to involve the XIIth nucleus in macrovibrissae whisking control was totally unknown until now. Since other recent experiments demonstrated that: 1) the mesencephalic trigeminal nucleus (Me5) neurons respond to both spontaneous and artificial movements of macrovibrissae, and that 2) the Me5 peripheral terminals provide a monosynaptic sensory innervation to the macrovibrissae, the present study was aimed at analyzing a possible role of the Me5 nucleus as a relay station in the sensory-motor loop that involves the XIIth nucleus neurons in rhythmic whisking control. Two tracers were used in the same animal: Fluoro Gold, which was injected into the whisker-pad to retrogradely label the hypoglossal whisker-pad projection neurons, and Dil, which was instead injected into the Me5 to label its projections to these hypoglossal neurons. Results demonstrated that terminals of the Me5 neurons monosynaptically target the hypoglossal whisker-pad projection neurons. The functional role of this sensory-motor connection is discussed, with particular regard to a hypothesized proprioceptive reflex in whisker-pad extrinsic muscles that can be elicited by the activation of the Me5 macrovibrissae receptors.
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Pagine da753
Pagine a761
Pagine totali-
RivistaExperimental brain research
Attiva dal 1966
Editore: Springer - Berlin
Paese di pubblicazione: Germania
Lingua: multilingue
ISSN: 0014-4819
Titolo chiave: Experimental brain research
Titolo proprio: Experimental brain research.
Titolo abbreviato: Exp. brain res.
Titoli alternativi:
  • Experimentation cerebrale
  • Experimentelle Hirnforschung
  • Experimental brain research (Print)
Numero volume della rivista234
Fascicolo della rivista-
Verificato da referee-
Stato della pubblicazionePublished version
Indicizzazione (in banche dati controllate)-
Parole chiaveMesencephalic trigeminal nucleus, Hypoglossal neurons · Me5-XIIth sensory-motor circuit, Proprioceptive reflex · Whisker-pad extrinsic muscles · Rat
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Strutture CNR
  • ISN — ISN - Sede secondaria di Catania
Moduli/Attività/Sottoprogetti CNR
  • ME.P02.011.001 : Markers molecolari nelle malattie ereditarie e tumori del Sistema Nervoso
Progetti Europei-