Consiglio Nazionale delle Ricerche

Tipo di prodottoArticolo in rivista
TitoloThe motor inhibition system in Parkinson's disease with levodopa-induced dyskinesias.
Anno di pubblicazione2015
FormatoElettronico
Autore/iAntonio Cerasa 1, Giulia Donzuso 1, Maurizio Morelli 2, Graziella Mangone 1, Maria Salsone 1, Luca Passamonti 1, Antonio Augimeri 1, Gennarina Arabia 2, and Aldo Quattrone 1,2
Affiliazioni autori1. Consiglio Nazionale delle Ricerche, IBFM, Catanzaro, Italy 2. Universita degli studi "Magna Graecia", Clinica Neurologica, Catanzaro, Italy
Autori CNR e affiliazioni
  • ANTONIO AUGIMERI
  • ALDO QUATTRONE
  • LUCA PASSAMONTI
  • ANTONIO CERASA
  • MARIA SALSONE
Lingua/e
  • inglese
AbstractBACKGROUND: Parkinson's disease is primarily a disorder of response initiation characterized by an excessive motor inhibition, whereas levodopa-induced dyskinesias are clearly a clinical expression of disinhibition of movements. OBJECTIVE: That levodopa-induced dyskinesias are linked to dysfunctions of inhibitory brain network has recently been proposed, but no investigation of behavioral performance during action inhibition task in these patients has been published. METHODS: Twenty-four Parkinson's disease patients with or without levodopa-induced dyskinesias tested on or off their medications underwent functional magnetic resonance imaging investigation during the execution of a stop-signal inhibition task. In particular, we were interested in evaluating the neural correlates of stop-related conditions: StopInhibit task (in which patients had to successfully inhibit their responses) and StopRespond task (Stop trials with erroneous button press). Both tasks were compared against Go trials. RESULTS: Levodopa intake in dyskinetic patients tended to worsen inhibitory control during the StopInhibit task, while significantly affecting the ability to monitor motor responses when patients failed to stop (StopRespond task). Functional analysis showed that, during the StopInhibit task, dyskinetic patients were characterized by decreased activity of the right inferior frontal cortex after levodopa intake, whereas patients without dyskinesias showed a reverse effect. A similar group × levodopa interaction effect was detected in the medial frontal cortex during the execution of the StopRespond task, in which dyskinetic patients showed increased activity after dopaminergic therapy CONCLUSIONS: Our study demonstrated that levodopa intake in dyskinetic patients tends to alter the functioning of some parts of the neural network involved in motor inhibition. © 2015 International Parkinson and Movement Disorder Societ
Lingua abstractinglese
Altro abstract-
Lingua altro abstract-
Pagine da1912
Pagine a1920
Pagine totali-
RivistaMovement disorders (Online)
Attiva dal 1986
Editore: John Wiley & Sons - New York, N.Y.
Paese di pubblicazione: Stati Uniti d'America
Lingua: inglese
ISSN: 1531-8257
Titolo chiave: Movement disorders (Online)
Titolo proprio: Movement disorders (Online)
Titolo abbreviato: Mov. disor. (Online)
Numero volume della rivista30
Fascicolo della rivista14
DOI10.1002/mds.26378
Verificato da referee-
Stato della pubblicazionePublished version
Indicizzazione (in banche dati controllate)
  • PubMed (Codice:26275050)
Parole chiavelevodopa-induced dyskinesias, stopsignal reaction time, motor inhibition, inferior frontal cortex, medial frontal cortex
Link (URL, URI)-
Titolo parallelo-
Licenza-
Scadenza embargo-
Data di accettazione-
Note/Altre informazioniPubblicato on-line: 14 Agosto 2015
Strutture CNR
  • IBFM — IBFM - Sede secondaria di Germaneto
Moduli/Attività/Sottoprogetti CNR
  • ME.P02.028.001 : Neuroimaging clinico dei disordini neurodegenerativi del movimento
Progetti Europei-
Allegati