Consiglio Nazionale delle Ricerche

Tipo di prodottoArticolo in rivista
TitoloMetabolic networks underlying cognitive reserve in prodromal Alzheimer disease: A European Alzheimer Disease Consortium Project
Anno di pubblicazione2013
Formato
  • Elettronico
  • Cartaceo
Autore/iMorbelli, Silvia D.; Perneczky, Robert; Drzezga, Alexander E.; Frisoni, Giovanni Battista; Caroli, Anna; Van Berckel, Bart NM M; Ossenkoppele, Rik; Guedj, Éric; Didic, Mira; Brugnolo, Andrea; Naseri, Mehrdad; Sambuceti, Gianmario; Pagani, Marco; Nobili, Flavio Mariano
Affiliazioni autoriUniversita degli Studi di Genova; Technische Universitat Munchen; Imperial College London; Universitat zu Koln; IRCCS Centro San Giovanni di Dio Fatebenefratelli; Laboratori Negri Bergamo; VU University Medical Center; Aix Marseille Universite; Istituto Di Scienze E Tecnologie Della Cognizione, Rome; Karolinska University Hospital
Autori CNR e affiliazioni
  • MARCO PAGANI
Lingua/e
  • inglese
AbstractThis project aimed to investigate the metabolic basis for resilience to neurodegeneration (cognitive reserve) in highly educated patients with prodromal Alzheimer disease (AD). Methods: Sixty-four patients with amnestic mild cognitive impairment who later converted to AD dementia during follow-up, and 90 controls, underwent brain 18F-FDG PET. Both groups were divided into a poorly educated subgroup (42 controls and 36 prodromal AD patients) and a highly educated subgroup (48 controls and 28 prodromal AD patients). Brain metabolism was first compared between education-matched groups of patients and controls. Then, metabolism was compared between highly and poorly educated prodromal AD patients in both directions to identify regions of high education-related metabolic depression and compensation. The clusters of significant depression and compensation were further used as volumetric regions of interest (ROIs) in a brain interregional correlation analysis in each prodromal AD subgroup to explore metabolic connectivity. All analyses were performed by means of SPM8 (P , 0.001 uncorrected at peak level, P , 0.05 false discovery rate-corrected at cluster level; age, sex, Mini-Mental State Examination score, and center as nuisance). Results: Highly educated prodromal AD patients showed more severe hypometabolism than poorly educated prodromal AD patients in the left inferior and middle temporal gyri and the left middle occipital gyrus (ROI depression). Conversely, they showed relative hypermetabolism in the right inferior, middle, and superior frontal gyri (ROI compensation). The sites of compensation, mainly corresponding to the right dorsolateral prefrontal cortex (DLFC), showed wide metabolic correlations with several cortical areas in both hemispheres (frontotemporal cortex, parahippocampal gyrus, and precuneus) in highly educated prodromal AD patients but not in poorly educated prodromal AD patients. To provide evidence on whether these metabolic correlations represent preservation of the physiologic networks of highly educated control subjects (neural reserve) or rather the recruitment of alternative networks (neural compensation), or a combination of the two, we performed metabolic connectivity analysis of the DLFC in highly educated controls as well. The correlation sites of right DLFC partly overlapped those of highly educated prodromal AD patients but were less extended. Conclusion: The present findings suggest that highly educated prodromal AD patients can cope better with the disease thanks to neural reserve but also to the recruitment of compensatory neural networks in which the right DLFC plays a key role.
Lingua abstractinglese
Altro abstract-
Lingua altro abstract-
Pagine da894
Pagine a902
Pagine totali-
RivistaThe Journal of nuclear medicine (1978)
Attiva dal 1978
Editore: Society of Nuclear Medicine. - [New York]
Paese di pubblicazione: Stati Uniti d'America
Lingua: inglese
ISSN: 0161-5505
Titolo chiave: The Journal of nuclear medicine (1978)
Titolo proprio: The Journal of nuclear medicine (1978)
Titolo abbreviato: J. nucl. med. (1978)
Titolo alternativo: JNM (1978)
Numero volume della rivista54
Fascicolo della rivista6
DOI10.2967/jnumed.112.113928
Verificato da refereeSì: Internazionale
Stato della pubblicazione-
Indicizzazione (in banche dati controllate)
  • Scopus (Codice:2-s2.0-84878644152)
Parole chiaveAlzheimer's disease, Cognitive reserve; positron emission tomography, Metabolic connectivity, Mild cognitive impairment
Link (URL, URI)http://www.scopus.com/record/display.url?eid=2-s2.0-84878644152&origin=inward
Titolo parallelo-
Licenza-
Scadenza embargo-
Data di accettazione-
Note/Altre informazioni-
Strutture CNR
  • ISTC — Istituto di scienze e tecnologie della cognizione
Moduli/Attività/Sottoprogetti CNR
  • ME.P02.015.001 : Neuropatologie e bisogni individuali: diagnostica per immagini, assessment linguistico-cognitivo, counseling genetico e trattamento riabilitativo
Progetti Europei-
Allegati
2013 JNM Cognitive Reserve in AD EADC FDG PET
Tipo documento: application/pdf

Dati associati a vecchie tipologie
I dati associati a vecchie tipologie non sono modificabili, derivano dal cambiamento della tipologia di prodotto e hanno solo valore storico.
Editore
  • Society of Nuclear Medicine, New York (Stati Uniti d'America)