Consiglio Nazionale delle Ricerche

Tipo di prodottoArticolo in rivista
TitoloLipid rafts: integrated platforms for vascular organization offering therapeutic opportunities
Anno di pubblicazione2015
Formato
  • Elettronico
  • Cartaceo
Autore/iAnna Laurenzana; Gabriella Fibbi; Anastasia Chillà; Giancarlo Margheri; Tommaso Del Rosso; Elisabetta Rovida; Mario Del Rosso; Francesca Margheri
Affiliazioni autoriSection of Experimental Pathology and Oncology, Department of Experimental and Clinical Biomedical Sciences, University of Florence,Viale GB Morgagni 50, 50134 Florence, Italy; Institute of Complex Systems (ISC), Consiglio Nazionale delle Ricerche (CNR),Via Madonna del Piano 10.50019,Sesto Fiorentino, Florence, Italy; Department of Physics, Pontificia Universidade Catolica do Rio de Janeiro, Rio de Janeiro, Brazil; Istituto Toscano Tumori, Florence, Italy
Autori CNR e affiliazioni
  • GIANCARLO MARGHERI
Lingua/e
  • inglese
AbstractResearch on the nanoscale membrane structures known as lipid rafts is relevant to the fields of cancer biology, inflammation and ischaemia. Lipid rafts recruit molecules critical to signalling and regulation of the invasion process in malignant cells, the leukocytes that provide immunity in inflammation and the endothelial cells that build blood and lymphatic vessels, as well as the patterning of neural networks. As angiogenesis is a common denominator, regulation of receptors and signalling molecules critical to angiogenesis is central to the design of new approaches aimed at reducing, promoting or normalizing the angiogenic process. The goal of this review is to highlight some of the key issues that indicate the involvement of endothelial cell lipid rafts at each step of so-called 'sprouting angiogenesis', from stimulation of the vascular endothelial growth factor to the choice of tip cells, activation of migratory and invasion pathways, recruitment of molecules that guide axons in vascular patterning and maturation of blood vessels. Finally, the review addresses opportunities for future studies to define how these lipid domains (and their constituents) may be manipulated to stimulate the so-called 'normalization' of vascular networks within tumors, and be identified as the main target, enabling the development of more efficient chemotherapeutics and cancer immunotherapies.
Lingua abstractinglese medio (1100-1500)
Altro abstract-
Lingua altro abstract-
Pagine da1537
Pagine a1557
Pagine totali-
RivistaCellular and molecular life sciences (Electron. ed.)
Attiva dal 1997
Editore: Birkhäuser - Basel
Paese di pubblicazione: Svizzera
Lingua: inglese
ISSN: 1420-9071
Titolo chiave: Cellular and molecular life sciences (Electron. ed.)
Titolo proprio: Cellular and molecular life sciences. (Electron. ed.)
Titolo abbreviato: Cell. mol. life sci. (Electron. ed.)
Titolo alternativo: CMLS (Electron. ed.)
Numero volume della rivista72
Fascicolo della rivista8
DOI10.1007/s00018-014-1814-x
Verificato da refereeSì: Internazionale
Stato della pubblicazionePublished version
Indicizzazione (in banche dati controllate)
  • Scopus (Codice:2-s2.0-84925457941)
  • ISI Web of Science (WOS) (Codice:000351456000008)
Parole chiaveEndothelial cell, Angiogenesis, Vascular guidance, Vessel maturation, Plasmonic Spectroscopies
Link (URL, URI)https://link.springer.com/article/10.1007/s00018-014-1814-x
Titolo parallelo-
Licenza-
Scadenza embargo-
Data di accettazione-
Note/Altre informazioniDate: 01 Jan 2015. Review.
Strutture CNR
  • ISC — ISC - Sede secondaria di Firenze - Sesto Fiorentino
Moduli/Attività/Sottoprogetti CNR
  • MD.P02.017.001 : comportamento dinamico di sistemi complessi
Progetti Europei-
Allegati
Lipid rafts: integrated platforms for vascular organization offering therapeutic opportunities (documento privato )
Descrizione: published version
Tipo documento: application/pdf