Consiglio Nazionale delle Ricerche

Tipo di prodottoAbstract in rivista
TitoloClique of functional hubs orchestrates population bursts in developmentally regulated neural networks
Anno di pubblicazione2015
Formato
  • Elettronico
  • Cartaceo
Autore/iAlessandro Torcini, Stefano Luccioli, Paolo Bonifazi, Eshel Ben-Jacob, Ari Barzilai
Affiliazioni autoriIstituto dei Sistemi Complessi - CNR, Sesto Fiorentino (Italy) Beverly and Sackler Faculty of Exact Sciences School of Physics and Astronomy, Tel Aviv University, 69978 Ramat Aviv, Israel Department of Neurobiology, George S. Wise Faculty of Life Sciences and Sagol School of Neuroscience, Tel Aviv University, Israel
Autori CNR e affiliazioni
  • STEFANO LUCCIOLI
  • ALESSANDRO TORCINI
Lingua/e
  • inglese
AbstractIt has recently been discovered that single neuron stimulation can impact network dynamics in immature and adult neuronal circuits. Here we report a novel mechanism which can explain in developing neuronal circuits, typically composed of only excitatory cells, the peculiar role played by a few specific neurons in promoting/arresting the population activity. For this purpose, we consider a standard neuronal network model, with short-term synaptic plasticity, whose population activity is characterized by bursting behavior. The addition of developmentally regulated constraints on single neuron excitability and connectivity leads to the emergence of functional hub neurons, whose stimulation/deletion is critical for the network activity. Functional hubs form a clique, where a precise sequential activation of the neurons is essential to ignite collective events without any need for a specific topological architecture. Unsupervised time-lagged firings of supra-threshold cells, in connection with coordinated entrainments of near-threshold neurons, are the key ingredients to orchestrate population activity.
Pagine daAbstract: G50.00004
Pagine a-
Pagine totali-
RivistaBulletin of the American Physical Society
Titolo chiave: Bulletin of the American Physical Society
Numero volume della rivista60
Fascicolo della rivista1
DOI-
Verificato da referee-
Stato della pubblicazionePublished version
Indicizzazione (in banche dati controllate)
  • Google Scholar (Codice:ZoHwWPUAAAAJ)
Parole chiavereti neurali
Link (URL, URI)http://meetings.aps.org/Meeting/MAR15/Session/G50.4
Titolo parallelo-
Scadenza embargo-
Licenza-
Data di accettazione-
Note/Altre informazioniAPS March Meeting 2015, Monday-Friday, March 2-6, 2015; San Antonio, Texas.
Strutture CNR
  • ISC — Istituto dei sistemi complessi
Moduli/Attività/Sottoprogetti CNR
  • MD.P02.017.001 : comportamento dinamico di sistemi complessi
  • DFM.AD004.072.001 : Laboratorio Congiunto Italo-Israeliano di Neuroscienze
Progetti Europei-
Allegati

Dati associati a vecchie tipologie
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Editore
  • APS, American physical society, College Park, MD (Stati Uniti d'America)
Lingua abstractinglese