Consiglio Nazionale delle Ricerche

Tipo di prodottoArticolo in rivista
TitoloDevelopmental vulnerability of synapses and circuits associated with neuropsychiatric disorders.
Anno di pubblicazione2013
FormatoCartaceo
Autore/iPeter Penzes1,2,+,*, Andres Buonanno3,+, Maria Passafaro4,5,+, Carlo Sala4,6,+, Robert A. Sweet7,8,
Affiliazioni autori1 Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA 2 Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA 3 Section on Molecular Neurobiology, Eunice Shriver Kennedy NICHD, National Institutes of Health, Program of Developmental Neurobiology, Bethesda, Maryland, USA 4 CNR Institute of Neuroscience and Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy 5 Dulbecco Telethon Institute, CNR, Institute of Neuroscience, Milan, Italy 6 Neuromuscular Diseases and Neuroimmunology, Neurological Institute and Foundation 'Carlo Besta', Milan, Italy 7 Department of Psychiatry, University of Pittsburgh School of Medicine, Biomedical Science Tower, Pittsburgh, Pennsylvania, USA 8 VISN 4 Mental Illness Research, Education and Clinical Center, VA Pittsburgh Healthcare System, Biomedical Science Tower, Pittsburgh, Pennsylvania, USA 9 Department of Neurology, University of Pittsburgh School of Medicine, Biomedical Science Tower, Pittsburgh, Pennsylvania, USA
Autori CNR e affiliazioni
  • MARIA PASSAFARO
  • CARLO SALA
Lingua/e
  • inglese
AbstractPsychiatric and neurodegenerative disorders, including intellectual disability, autism spectrum disorders (ASD), schizophrenia (SZ), and Alzheimer's disease, pose an immense burden to society. Symptoms of these disorders become manifest at different stages of life: early childhood, adolescence, and late adulthood, respectively. Progress has been made in recent years toward understanding the genetic substrates, cellular mechanisms, brain circuits, and endophenotypes of these disorders. Multiple lines of evidence implicate excitatory and inhibitory synaptic circuits in the cortex and hippocampus as key cellular substrates of pathogenesis in these disorders. Excitatory/inhibitory balance - modulated largely by dopamine - critically regulates cortical network function, neural network activity (i.e. gamma oscillations) and behaviors associated with psychiatric disorders. Understanding the molecular underpinnings of synaptic pathology and neuronal network activity may thus provide essential insight into the pathogenesis of these disorders and can reveal novel drug targets to treat them. Here, we discuss recent genetic, neuropathological, and molecular studies that implicate alterations in excitatory and inhibitory synaptic circuits in the pathogenesis of psychiatric disorders across the lifespan.
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RivistaJournal of neurochemistry
Attiva dal 1956
Editore: Blackwell - Oxford
Paese di pubblicazione: Regno Unito
Lingua: inglese
ISSN: 0022-3042
Titolo chiave: Journal of neurochemistry
Titolo proprio: Journal of neurochemistry.
Titolo abbreviato: J. neurochem.
Titolo alternativo: JNC
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DOI10.1111/jnc.12261
Verificato da refereeSì: Internazionale
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Strutture CNR
  • IN — IN - Sede secondaria di Milano
Moduli/Attività/Sottoprogetti CNR
  • ME.P02.007.001 : Farmacologia Cellulare e Molecolare delle Cellule Nervose
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Developmental vulnerability of synapses and circuits associated with neuropsychiatric disorders. (documento privato )
Tipo documento: application/pdf