Consiglio Nazionale delle Ricerche

Tipo di prodottoArticolo in rivista
TitoloUsing hippocampal-striatal loops for spatial navigation and goal-directed decision-making.
Anno di pubblicazione2012
Autore/iChersi, Fabian [1]; Pezzulo, G. [1] [2]
Affiliazioni autori[1] CNR-ISTC, Roma; [2] CNR-ILC
Autori CNR e affiliazioni
  • inglese
AbstractThe hippocampus plays a central role in spatial representation, declarative and episodic memory. In this area, so-called place cells possess high spatial selectivity, firing preferentially when the individual is within a small area of the environment. Interestingly, it has been found in rats that these cells can be active also when the animal is outside the location or context of their corresponding place field producing so-called ''forward sweeps''. These typically occur at decision points during task execution and seem to be utilized, among other things, for the evaluation of potential alternative paths. Anticipatory firing is also found in the ventral striatum, a brain area that is strongly interconnected with the hippocampus and is known to encode value and reward. In this paper, we describe a biologically based computational model of the hippocampalventral striatum circuit that implements a goal-directed mechanism of choice, with the hippocampus primarily involved in the mental simulation of possible navigation paths and the ventral striatum involved in the evaluation of the associated reward expectancies. The model is validated in a navigation task in which a rat is placed in a complex maze with multiple rewarding sites. We show that the rat mentally activates place cells to simulate paths, estimate their value, and make decisions, implementing two essential processes of model-based reinforcement learning algorithms of choice: look-ahead prediction and the evaluation of predicted states.
Lingua abstractinglese
Altro abstract-
Lingua altro abstract-
Pagine da125
Pagine a129
Pagine totali-
RivistaCognitive processing (Print)
Attiva dal 2000
Editore: Springer - Berlin
Paese di pubblicazione: Germania
Lingua: inglese
ISSN: 1612-4782
Titolo chiave: Cognitive processing (Print)
Titolo proprio: Cognitive processing. (Print)
Titolo abbreviato: Cogn. process. (Print)
Numero volume della rivista13
Fascicolo della rivista1
Verificato da refereeSì: Internazionale
Stato della pubblicazione-
Indicizzazione (in banche dati controllate)-
Parole chiaveSpatial navigation  Mental simulation  Hippocampal-striatal circuit  Neural network  Computational model
Link (URL, URI)
Titolo parallelo-
Scadenza embargo-
Data di accettazione-
Note/Altre informazioniID_PUMA: /cnr.ilc/2012-A0-011
Strutture CNR
  • ILC — Istituto di linguistica computazionale "Antonio Zampolli"
  • ISTC — Istituto di scienze e tecnologie della cognizione
Moduli/Attività/Sottoprogetti CNR
  • IC.P02.004.002 : Architetture bio-computazionali del lessico mentale
Progetti Europei-
Using hippocampal-striatal loops for spatial navigation and goal-directed decision-making. (documento privato )
Tipo documento: application/pdf