Abscisic acid as a new human hormone regulating glycemia
Il 20/03/2017 ore 14.30 - 15.30
Sala Conferenze, Area della Ricerca NA1, Via P. Castellino, 111 80131 Napoli
Prof. Santina Bruzzone from the Department of Experimental Medicine, Università degli studi di Genova, will give a seminar on the role of abscisic acid (ABA), mainly known as a plant hormone, in the regulation of glycemia. She demonstrated that ABA is also a human hormone, regulating glycemia in humans through several mechanisms: i) by increasing insulin-independent muscle and adipose tissue glucose uptake; ii) by stimulating insulin release; iii) by stimulating the release of the incretin Glucagon Like Peptide-1. We identified the ABA receptor (LANCL2), and we generated a LANCL2-KO mouse strain. Notably, ABA plasma levels increase in healthy, but not in diabetic, subjects undergoing an oral glucose tolerance test and oral ABA improves glycemic control in rodents and in healthy humans. More recently, her group has demonstrated that ABA induces the browning of murine adipocytes in vitro and in vivo.
ABA represents the only other hormone with a hypoglycaemic function, besides insulin, warranting further studies aimed at elucidating the physiology as well as the possible dysfunction of the ABA/LANCL2 system in humans.
Cnr - Istituto di biochimica delle proteine
Via P. Castellino, 111 80131 Napoli
Modalità di accesso: ingresso libero