Biofotonica per sensing intracellulare - BALDINI (DIT.AD010.047)

Thematic area

Engineering, ICT and technologies for energy and transportation

Project area

Structure responsible for the research project

Institute of applied physics "Nello Carrara" (IFAC)

Project manager

FRANCESCO BALDINI
Phone number: 055 5226323
Email: f.baldini@ifac.cnr.it

Abstract

The possibility of combining diagnostics and therapy at intracellular level is the objective of this research line. This objective is pursued by means of the design, realisation and characterization of functionalised nanostructures capable to internalise at intracellular level fluorescent probes able to act at the same time as molecular biomarkers of intracellular target and as therapeutic drugs.
Particular attention is given to antisense oligonucleotidic switches, suitable molecules which turn on or modify their light emission on molecular interaction with well-defined molecular mRNA targets and which, at the same time, provides the pharmacological silencing activity preventing the overexpression of proteins associated to pathologic conditions.
A not negligible activity is also devoted to the nanocarriers capable to enter the cell and to the different strategies to be adopted to facilitate their internalization

Goals

Sviluppo di sonde fluorescenti intracellulari in grado di agire simultaneamente come elemento diagnostico e terapeutico in grado sia di rivelare la presenza di un determinato mRNA a livello intracellulare sia di svolgere un'azione farmacologica dentro la cellula, fornendo così uno strumento di estrema utilità nell'ambito delle strategie moderne di terapia personalizzata

Start date of activity

01/01/2013

Keywords

Faro molecolare, teranostica, drug delivery

Last update: 02/12/2023