Research project

Ricerca finalizzta GR 2016-02362247 (DSB.AD004.265)

Thematic area

Biomedical sciences

Project area

Neuroscienze (DSB.AD004)

Structure responsible for the research project

Institute of genetics and biophysics "Adriano Buzzati Traverso" (IGB)

Project manager

MASSIMILIANO CAIAZZO
Phone number: +390816132401
Email: massimiliano.caiazzo@gmail.com

Abstract

microRNAs (miRNAs) regulate fundamental cell processes. Dysregulation of miRNA expression and function is reported in
various diseases including cancer, metabolic disorders as well as neurological disorders. Circulating miRNAs have been
proposed to mirror physiological and pathological conditions suggesting their use as biomarkers for various diseases. We
will focus on a case-control study cohort (N=1000) of subjects recruited at the IRCCS Neuromed for which a deep clinical
characterization and genome-wide sequencing data are available. This study will enable to identify novel circulating
biomarkers for Parkinson¿s disease (PD). Further, the project will give new insights on the involvement of miRNAs in the
etiology of PD and in the understanding of the genetics of the disease thus opening avenues for novel therapeutic
strategies.

Start date of activity

14/02/2019

Keywords

circulating miRNAs in Parkinson's disease, association analysis, biomarkers

Last update: 10/12/2023