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  5. Role of genetic polymorphism of the cladribine-apoptotic pathway on T cell metabolism and susceptibility to Multiple Sclerosis (DSB.AD001.089)
Research project

Role of genetic polymorphism of the cladribine-apoptotic pathway on T cell metabolism and susceptibility to Multiple Sclerosis (DSB.AD001.089)

Thematic area

Biomedical sciences

Project area

Oncologia e Immunologia (DSB.AD001)

Structure responsible for the research project

Institute Experimental Endocrinology and Oncology "Gaetano Salvatore" (IEOMI)

Project manager

GIUSEPPE MATARESE
Phone number: 0817463058
Email: g.matarese@ieos.cnr.it

Abstract

In this proposal, we aim at investigating the effect of a number of single nucleotide polymorphisms (SNPs) in the adenosine deaminase (ADA), deoxycytidine kinase (DCK) and 5'-Nucleotidase (NT5C2), and in the key regulators of the DNA repair and apoptotic mechanisms that can be induced by Cladribine (2-CdA, 2-chloro-2'-deoxyadenosine) (AKT, p53, BRCA 1, BRCA 2, LIG 4, NBS1, CYP3A4, XRCC 5, MDM) on T cell metabolic programs in healthy controls and patients with relapsing-remitting multiple sclerosis (RRMS). These studies should provide the possibility to link different polymorphisms, T cell metabolism and RRMS progression.

Goals

Valutare l'effetto di diversi polimorfismi in geni che possono essere indotti dalla cladribina sull'attivazione di specifici programmi metabolici nelle cellule T di controlli sani e di pazienti affetti da SM recidivante-remittente.

Start date of activity

17/10/2016

Keywords

Tconv, Treg, SNPs

Last update: 09/07/2025