We report the first crystal structure of the checkpoint enzyme that in the background of congenital glycoprotein misfold disease flags misfolded glycoproteins for endoplasmatic reticulum retention. The study uses the Arabidopsis thaliana plant as an in vivo system. It is a collaboration between the Oxford Glycobiology Institute at the Department of Biochemistry, of the University of Oxford, United Kingdom; the Institutes of Sciences of Food Production and Crystallography of the Consiglio Nazionale delle Ricerche; the Diamond Light Source and Research Complex at Harwell, Didcot also in the United Kingdom. The paper describing the study has been published in the journal PNAS
A new study has successfully established the first gene therapy approach to reduce or prevent a-synuclein toxic aggregates that are causing neuronal dysfunctions and loss in Parkinson’s disease. These results pave the way for testing gene therapy approaches for the treatment of neurodegenerative diseases that might affect also large brain areas. The study has been published in 'Molecular Therapy'
The event, co-organised by Cnr-Ibimet, will cover thematic areas ranging from horticulture to innovative technological solutions aimed at improving the efficiency and the management of urban green infrastructures. Transversal visions in which landscape architecture and environmental engineering meet the functional management of horticulture in the urban environment in order to maximise ecosystem service provision
The Short Term Mobility (STM) Program enables highly qualified foreign researchers, belonging to foreign Universities and Research Institutions of clear international standing, to be invited to carry out research in cooperation with Cnr Institutes. The call 2017 is open until September 29
A brand-new, long-term and globally available satellite soil moisture dataset now allows the Research Institute for Geo-Hydrological Protection of National Research Council (Irpi-Cnr) to closely monitor and predict the impact of the current drought situation. This near-real-time product is produced as part of the Copernicus Climate Changes Service (C3S) portfolio of the European Commission. Irpi-Cnr has been involved in its pre-operational development and assessment
A study published in the journal Pediatrics outlined the prospect of a new hereditary transmission mechanism of Incontinentia pigmenti disease. A team of researchers from the Institute of genetics and biophysics of Cnr of Naples with the Pediatric hospital Bambino Gesù and the University of Ferrara, discovered the novel forms of familiarity in Incontinentia pigmenti, by genetically characterizing the molecular alteration in somatic and germline cells of IP male father, although to date it was referring to the exclusive maternal inheritance
The First Italian Citizen Science Conference will be held in Rome in November 23rd – 25th 2017, with the aim to explore the state of the art in this relatively new promising field. The Conference is organized by the Italian National Academy of Sciences with the support of the Italian National Research Council (Cnr)
The results of a recent research aimed to re-describe the limnological conditions of the Lake Río Cuartomore, which is a maar lake, with meromictic conditions